Clinical Neuroscience

[Autoimmune aspects of myasthenia gravis]

SZOBOR Albert1, BOZSÓKI Sándor1, GÁSPÁRDY Géza1

JANUARY 01, 1969

Clinical Neuroscience - 1969;22(01)

[Recent research suggests that an autoimmune process may also play a role in the pathomechanism of myesthenia gravis. In our own studies, 45 patients with myasthenia were serologically tested for antibodies against striated muscle, anti-gammaglobulin factor and anti-thyroid antibodies, and 46.6% were found to have anti-muscle antibodies. No serological reactions against muscle were detected in 52 control subjects. The positivity of anti-muscle immune reactions showed no correlation with patient age, sex, clinical status, prognosis, thymus surgery or irradiation. There are several possibilities for interpreting the immune positivity observed in myesthenia. One such possibility is the question of myasthenia beginning with respiratory tract infection, with a percentage approximately equal to the incidence of positive immune reactions and lymphorrhagia in muscle. The pronounced role of thymoma in the initiation of immune reactivity has not been established. Considering the possibility of a somatic mutation, the immunostimulatory role of the processes involved cannot be verified. The role of immune-serologically positive diseases associated with myasthenia is emphasized, based on the literature and our own material, but no explanation for the immunological implications of myasthenia is obtained based on disease association. Based on our studies, we outline our hypothesis that the immunobiological link of myasthenia is not causal and direct, but an indirect mechanism via the thymus. ]

AFFILIATIONS

  1. Budapest Főváros XIII. ker. Tanács Róbert Károly körúti Kórház Organikus Idegosztály és az Országos Rheuma és Fürdőügyi Intézet Serologiai Laboratóriuma

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