Lege Artis Medicinae

[The mRNA vaccine that changes the endgame – The chronicle of a Nobel Prize]

KOVÁCS Sándor

NOVEMBER 23, 2023

Lege Artis Medicinae - 2023;33(10-11)

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Further articles in this publication

Lege Artis Medicinae

[Disturbances of lipid metabolism in endocrine disorders ]

HARANGI Mariann, ZSÍROS Noémi, TÓTH Nóra

[Dyslipidemia plays a crucial role in the pathogenesis of several cardiovascular diseases. In many patients, there is no primary disorder of the lipoprotein meta­bolism since the condition is caused by which­ever “nonlipid” etiology. These se­condary dyslipidemias are surprisingly common, and their background factors are often missed if they are not scrutinized systematically. Endocrine disorders are commonly associated with dyslipidemia, including hypothyroidism, diabetes mellitus, Cushing’s syndrome, acromegaly, hy­pogonadism, growth hormone deficiency, hyperprolactinemia, and polycystic ovary syndrome. Recognizing these conditions is essential since the lipid abnormalities respond well to the treatment of primary dis­orders in most cases. Thus diagnosing the endocrine diseases during the routine investigation of dyslipidemia patients is es­sential for effective treatment and preven­tion of cardiovascular diseases.]

Lege Artis Medicinae

[The non-doctor healthcare professionals’ income evolution between 2004–2021 in Hungary]

BONCZ Imre, ELMER Diána, NÉMETH Noémi, CSÁKVÁRI Tímea, ÁGOSTON István, KAJOS Luca Fanni, SAÁGHY Andrea, KÁSÁDI Márta, ENDREI Dóra

[This study aims to examine the average monthly income of non-doctor healthcare professionals employed in Hungary between 2004–2021, with special regard to 2021.

Data were derived from the database of the National Directorate General for Hospitals. Non-doctor healthcare professionals employed full-time in all public health services were included in our time-series analysis. In our institutional-level analysis, we considered all non-doctor healthcare professionals employed in state owned hospitals. 

In Hungary, the average monthly income of full-time non-doctor healthcare professionals reached the national average gross income level in the period 2017-2019, and then surpassed it from 2020 onward. In 2020, the average monthly income of hospital based non-doc­tor healthcare professionals at national le­vel was 447,956 HUF/1,276 €, while in 2021, it was 495,933 HUF/1,383 € (+11%). In 2021 it was 561,412 HUF/1,566 € in national institutes, 538,055 HUF/1,501 € in clinical centers, 536,196 HUF/1,496 € in ca­pital hospitals, 473,044 HUF/1,319 € in county hospitals and 461,473 HUF/1,287 € in urban hospitals. 

In Hungary, the average monthly income of full-time non-doctor healthcare professionals reached the national average gross income in the period between 2017-2019 and then surpassed it from 2020 onward. In 2021, the average monthly income of hospital based non-doctor healthcare professionals in Hungary was the highest in national institutes. There was a 1.73-fold difference between the lowest and the highest average income in institutions providing only acute or acute and chronic inpatient care.]

Lege Artis Medicinae

[Women’s mental health in the light of perinatal sciences: What we should know about postpartum mood disorders?]

CZINKÓCZI Annamária, VARGA Orsolya, VARGA Katalin

[It is generally believed that pregnancy, childbirth and the post partum period are magical periods in a women’s life. How­ever, research findings highlight also the dif­ficulties of this sensitive life stage. The aim of this study is to present the nature, risk factors, long-term consequences, fur­ther prevention and intervention options of postpartum disorders.]

Lege Artis Medicinae

[Fiume and the maritime public health of Hungary – with historic background]

BALÁZS Péter

[Fiume/Rijeka the fast developing Adriatic seaport of Hungary had a remarkable chapter in the history of this country. It became as corpus separatum i.e. not out of the Croatian Kingdom a part of Hungary in 1779. Thus the peace treaty 1920 of Trianon dealt with the city and its surrounding region in a specific chapter (Part III, Title V) after the WW1. The seaport’s story started in the first decades of the 18th century after the successful military campaigns against the Ottomans when the Habsburg Empire, inclusive Hungary seized the opportunity to take part in the lucrative Mediterranean maritime trading. However, the absolute precondition of this business was to prevent or contain the plague epidemic waves launched permanently out of the Eastern Mediterranean seaports. This endeavour dominated practically all activities of the maritime public health authorities the strict rules of which were created between 1755 and 1769. The Habsburg legislation combined successfully the ancient Mediterranean customs with the well-disciplined Austrian bureaucracy. One hundred year later, the first international sanitary conference in Paris (1851-52) tried only to relax the strict rules by maintaining the original principles. In Hungary, this valuable body of knowledge fell two times in oblivion. First when the self-conscious modern scientific microbiology swept away the obsolete empiric regula­tions. Secondly, when the loss of our seaport and the dying-out of Hungarian maritime trade dropped this knowledge out of our collective memory. Nevertheless, it was very useful to study the old documents since nowadays after the euphoria of “de­feating the epidemics” they are sending va­luable messages of a never-ending struggle in the field of macro- and microbiology. ]

Lege Artis Medicinae

[Hypoglycemia: pondering the important treatment options of elderly Diabetic patients ]

DOMBORÓCZKI Zsolt

[Hypoglycemia is a well-known, potentially life threatening, common, yet underesti­mated consequence of glucose-lowering treatment. Elderly patients have increased tendency to develop low blood sugar levels, since their detection threshold is decreasing and the counter-regulation weakens. This process is burdened by de­clining neurocognitive and somatic status of the patients. A frail elderly person is at greater risk of hypoglycemia complica­tions. Neuroglycopenic damage of the central nervous system, cerebral and myocardial ischemia, malignant heart rhythm disturbances can all have life-threatening consequences, but long-term mental and physical decline must also be considered as well. Prevention is essential, supported by careful education and prudent choice of antidiabetic drugs and insulin preparations. Use of non-hypoglycemic agents and a diet with individual amounts and compositions help to minimize the risk, avoid overtreatment, and implement efficient and safe therapy simultaneously.]

All articles in the issue

Related contents

Lege Artis Medicinae

[A short chronicle of three decades ]

KAPRONCZAY Katalin

[Hungarian professional periodicals started quite late in European context. Their publish­ing, editing and editorial philosophy were equally influenced by specific historical and political situations. Certain breaking points of history resulted in termina­tion of professional journals (War of In­de­pendence 1848-1849, First and Se­cond World Wars), however there were pe­riods, which instigated the progress of sciences and founding of new scientific journals. Both trends were apparent in years after the fall of former Hungarian regime in 1990. The structure of book and journal publishing has changed substantially, some publishers fell “victim” others started successfully as well. The latters include the then-established publishing house Literatura Medica and its own scientific journal, Lege Artis Me­di­cinae (according to its subtitle: New Hun­garian Medical Herald) issued first in 1990. Its appearance enhanced significantly the medical press market. Its scientific publications compete with articles of the well-established domestic medical journals however its philosophy set brand-new trends on the market. Concerning the medical community, it takes on its problems and provides a forum for them. These problems are emerging questions in health care, economy and prevention, in close interrelation with system of public health institutions, infrastructure and situation of those providing individual health services. In all of them, Lege Artis Medicinae follows consequently the ideas of traditional social medicine.]

Clinical Neuroscience

[Personalized treatment options for spinal muscular atrophy]

SZABÓ-TAYLOR Katalin, MOLNÁR Mária Judit

[Spinal muscular atrophy (SMA) is an autosomal recessive disease leading to progressive muscle weakness and atrophy, in severe cases also affecting the bulbar and respiratory muscles.The clinical spectrum of the disease is extremely variable, in the most severe cases resulting in perinatal death, while at the least severe end of the spectrum causing some motor deficits in old age without the loss of ambulation.]

Lege Artis Medicinae

[History of vaccine production in Hungary ]

ÓCSAI Lajos

[This study presents the complete history of the Hungarian vaccine production, partly in association with the process of fighting vaccine-preventable infectious diseases, and underlines the fact that every government actively contributed to the age-adjusted mandatory vaccination schedule of the past 140 years. It demonstrates the various achievements from the smallpox lymph production through the launch of diphtheria serum production at Phylaxia and the establishment of the National Public Health Institute (OKI) with its vaccine production and the later institutional transformation of OKI into Humán as economic corporation to its closure. Among all OKI’s vaccine production activities, this study focuses on the production of influenza vaccines, due to its international importance in the 1960s and 1970s. The vaccine production against diphtheria tetanus and pertussis stands out from Humán’s activities, and the tetanus component of this vaccine is still used in the products of a multinational vaccine manufacturer. ]

Clinical Neuroscience

Investigation of oxidative stress in patients with multifocal motor neuropathy

PATZKÓ Ágnes , DELI Gabriella , CSEH Tamás , BELEZNAY Zsuzsanna , NAGY Lajos , KÉKI Sándor, MIKE Andrea , PÁL Endre , KOMOLY Sámuel , ILLES Zsolt , CSONGOR Alexandra , PFUND Zoltán

Multifocal motor neuropathy (MMN) is a rare, immune-mediated illness attacking ex- clusively motor nerves. It is known that oxidative stress is present in peripheral neuropathies, but it has not been investigated MMN.

Clinical Neuroscience

[Headache registry in Szeged: Experiences regarding to migraine patients]

PLANDER Máté, TAJTI János, VÉCSEI László, SZOK Délia

[Using patient registries is essential both in clinical research and in medical practice. Headaches, more specifically migraines are one of the most common complaints that can detract the quality of a patient’s life and these complaints also have a significant socio-econo­mic effect. Our goal is to create a national Headache Registry and to also provide the pre-analysis of the registry’s database.

Our research is based on the national Multiple Sclerosis Registry, which we modified using the latest version of diagnostic criteria published by the International Headache Society. This clinical study contains data collected from patients suffering from migraines and currently receiving care at the Headache Outpatient Department at the Neurologic Clinic of the University of Szeged.

The data of 412 patients (363 wo­men and 49 men) suffering from migraine (migraine without aura: n = 313 and migraine with aura: n = 99) were added to the Headache Registry. The average age of participants was 44.1 ± 12.5 SD years. Regarding the attributes of migraine headaches we examined the following characteristics: localization, quality and intensity (based on the Visual Analogue Scale) of the pain, frequency (the number of headache days per month), medications (acute or prophylactic), comorbidities (depression, anxiety, hypertension, asthma, epilepsy and others), family history and the occurrence of stroke among patients.

Based on international expe­rience, patient registries are the most optimal systems for structured patient mo­nitoring. For high level management and long-term follow up of the patients the application of registries is essential. The registries include the detailed medical history and the diagnostic and therapeutic data of the patients, and they trace the changes during the follow up medical visits. Registries are able to record the entire course of the disease in digital way. The numerous data can be set out any time from the digital database. Extensive spread of patients’ registries is fundamental not only in every day clinical practice, but also in clinical research.]