Although headaches are often comorbid with psychological symptoms, the underlying psychological processes, e.g. the role of personality dimensions as headache determinants remains unclear. Studies found associations between headaches and various personality traits; according to the Big Five model of personality, persons suffering from headaches exhibit a higher rate in neuroticism, while a lower rate in extraversion, openness to experiences and positive emotions.

[Hypothyroidism is common in the elderly. Frequent causes of hypothyroidism include autoimmune disease of the thyroid gland, previous thyroid surgery and radioiodine therapy. Symptoms may be atypical, and the level of serum thyroid-stimulating hormone (TSH) must be measured as a part of the biochemical workup. Elevated serum TSH levels have to be confirmed with a repeated tests, which must be completed by measuring the serum thyroxine level too. The recommended and relevant replacement therapy for hypothyroidism is levothyroxine sodium administration. Le­vo­thyroxine sodium is orally only partially absorbed since it is affected by food, minerals, drugs and the composition of the tablet. The initial hormone replacement dose should be low if any heart disease is suspected. The main risk of levothyroxine sodium therapy is its over supplementation, the side effects of which may include anxiety, muscle atrophy, osteoporosis, and atrial fibrillation. Subclinical hypothyroidism with elevated serum TSH level but with a T4 level in its reference range may be considered as a mild form of hypothyroidism. Studies published so far did not prove the positive effect of substitution therapy for non-goitrous subclinical hypothyroidism, especially in elderly patients.]

[Multiple sclerosis (MS) may impact quality of life, careers and family plans of the affected individuals. The current treatments with disease modifying therapies aim to prevent people with MS (pwMS) from disability accumulation and progression. Different countries have different reimbursement policies resulting in inequalities in patient care among geographical regions. Access to anti-CD20 therapies for relapsing MS is restricted in Hungary because therapy of individual cases only is reimbursed. In the light of the latest research and national guidelines, 17 Hungarian MS experts agreed on 8 recommendations regarding relapsing pwMS using the Delphi round method. Strong agreement (> 80%) was achieved in all except one recommendation after three rounds, which generated a fourth Delphi round. The experts agreed on treatment initiation, switch, follow-up and discontinuation, as well as on special issues such as pregnancy, lactation, elderly population, and vaccination. Well-defined national consensus protocols may facilitate dialogue between policymakers and healthcare professionals and thus contribute to better patient care in the long run.]

[The possibility of detecting pancreatic cancer (PC) at a potentially curable stage depends on early diagnosis and the ability to identify and screen high-risk populations before symptoms appear. Identifying high-risk populations is challenging and optimal screening tools remain unclear (1).]