Hypertension and nephrology

[Lercanidipine in hypertension]


OCTOBER 20, 2016

Hypertension and nephrology - 2016;20(05)

[Lercanidipine is a third generation DHP type calcium antagonist. It’s antihypertensive efficacy is proven using in monotherapy or combined treatment as well. The main advantage compared with the first and second generation DHP calcium antagonists is that fewer side effects, especially the much less common ankle oedema. Renal protective effect has proven by experimental and clinical studies, but in the future more prospective randomized studies should be supported this benefit. The drug is very useful for diabetes, obesity associated with hypertension due to the metabolic „neutrality”. The key of successful antihypertensive is the high level persistence. From this point of view the lercanidipine is a very useful factor during the treatment.]



Further articles in this publication

Hypertension and nephrology

[Letter to the Reader]

A szerkesztôség

Hypertension and nephrology

[State Ceremony on the 150th Anniversary of the Birth of Sándor Korányi ]

RADÓ János

Hypertension and nephrology

[A new perspective on the extrarenal regulation of sodium and water balance]

AGÓCS Róbert István, SUGÁR Dániel, SULYOK Endre, SZABÓ J. Attila

[The regulation of the homeostasis of sodium and water is one of the oldest fields in medical research. Our article exhibits a new aspect of sodium balance: the concept of the regulated sodium storage taking place in the interstitium of the skin. We summarize the history of the research carried out in this area, beginning with the discovery of osmotically inactive sodium reservoirs to the localization of these buffers and the elucidation of the role of a regulating cutaneous cascade, which has an effect on blood pressure. Glycosaminoglycan (GAG) macromolecules present in the skin interstitium, come into reversible contact with the excess of dietary sodium intake. Thus in addition to the known role of the kidney, the above system may contribute to the regulation of sodium- and water balance and thereby to the regulation of blood pressure.]

Hypertension and nephrology

[Quality of Life: How Health is Considered. A European Comparison ]


Hypertension and nephrology

[The Great Fat Bluff]


All articles in the issue

Related contents

Hypertension and nephrology

[Association between cyclothymic affective temperament and hypertension]


[Affective temperaments (cyclothymic, hypertymic, depressive, anxious, irritable) are stable parts of personality and after adolescent only their minor changes are detectable. Their connections with psychopathology is well-described; depressive temperament plays role in major depression, cyclothymic temperament in bipolar II disorder, while hyperthymic temperament in bipolar I disorder. Moreover, scientific data of the last decade suggest, that affective temperaments are also associated with somatic diseases. Cyclothymic temperament is supposed to have the closest connection with hypertension. The prevalence of hypertension is higher parallel with the presence of dominant cyclothymic affective temperament and in this condition the frequency of cardiovascular complications in hypertensive patients was also described to be higher. In chronic hypertensive patients cyclothymic temperament score is positively associated with systolic blood pressure and in women with the earlier development of hypertension. The background of these associations is probably based on the more prevalent presence of common risk factors (smoking, obesity, alcoholism) with more pronounced cyclothymic temperament. The scientific importance of the research of the associations of personality traits including affective temperaments with somatic disorders can help in the identification of higher risk patient subgroups.]

Lege Artis Medicinae

[Pharmacotherapeutic strategies on treatment of patients with high cardiovascular risk based on the 2018 European Hypertension Guidelines]


[The new joint hypertension guidelines of the European Society of Hypertension and European Society of Cardiology will simultaneously be published in August, 2018 in the J. Hypertension and Eur. Heart J. on the diagnostics, evaluation, treatment and follow up of hypertensive patients. This guidelines put emphasis on definition, and therapeutic strategies in patients with high cardiovascular risk. In this paper I summarise the cardiovascular risk factors and put emphasis on possibilities of reduction of cardiovascular risk. ]

Lege Artis Medicinae

[The advantages of the combination of amlodipine and atorvastatin and the experiences with the therapy]


[Hypertension and hyperlipidaemia are two major risk factors, as well as a single factor, but together are even more responsible for the cardiovascular death, which still isn’t reduced significantly in Hungary. About 2.5 million people suffer from hypertension in Hungary, and almost half of them do not reach the target level, and two-thirds of them have hyperlipidaemia as well. These risk factors are associated with other diseases. Obviously these illnesses can not be treated only with one drug. The European guidelines of the treatment of hypertension (ESH/ESC 2013) emphasise the importance of priorital of two-drug combinations, there is an evidence for the fix combinations of patients with major multiple risk factors in the beginning of the therapy. We used the combination of amlodipine/ atorvastatin in the treatment of hypertension during a three month period. The level of the blood pressure decreased of 18/11 mmHg, the cholesterin and the triglicerid values decreased 0.56 and 0.7 mmol/l. The patients got advices for the right lifestyle as well. In conclusion it can found, that the fix-drug combinations can improve the adherence, and they can help in the rigorous control of hypertension to prevent and treat the car­diovascular diseases.]

Lege Artis Medicinae


CSIKY Botond

[According to national and international guidelines, thiazide diuretics are considered first-line antihypertensive agents. They lower blood pressure and cardiovascular risk efficiently without serious side effects in low-dose monotherapy or in combination with other antihypertensives. Furthermore, when given in combination with certain antihypertensive agents, a synergistic effect develops. Indapamide is a thiazide-like diuretic, virtually without metabolic side effects. Diuretics may have special benefit in the elderly and in certain target organ damage or concomittant disease (heart failure, hypervolaemia, etc). Adequate use of diuretic therapy can prevent hypertensive end-organ damage and other complications, and improves the patients' quality of life.]

Hypertension and nephrology

[Hypertension and pregnancy]

JÁRAI Zoltán, VÁRBÍRÓ Szabolcs

[Hypertension complicates approximately 10% of the pregnancies and with this high blood pressure is the most frequent cardiovascular comorbidity during pregnancy. Hypertension during pregnancy accounts for a substantial maternal and perinatal morbidity and mortality risk. In our review we focus on the forms, diagnosis and therapeutic possibilities of gestational hypertension according to the European and domestic guidelines.]