Clinical Neuroscience

Secretory meningioma with bone infiltration and orbital spreading

KÁLOVITS Ferenc1,2, TAKÁTS Lajos1, SOMOGYI Katalin3, GARZULY Ferenc3, TOMPA Márton2, KÁLMÁN Bernadette2,4

MARCH 30, 2019

Clinical Neuroscience - 2019;72(03-04)

DOI: https://doi.org/10.18071/isz.72.0141

Secretory meningioma is a rare form of meningiomas which differentiates from the meningothelial subtype. It is characterized by significant peritumor edema and distinct immunohistochemical and molecular genetic profiles. We present a middle aged female patient with secretory meningioma infiltrating the orbital bone from the primary cranial base location and causing exophthalmos, features rarely described with this tumor. Surgical resection was challenging because of the associated brain swelling and rich vascularization of the tumor. Imaging and immunohistochemical studies revealed characteristic hallmarks of secretory meningioma. While histologically it was a benign tumor, due to the orbital bone and soft tissue infiltration, postoperative management of neurological sequelae was challenging. This case highlights distinctive clinical, imaging and histological features along with individual characteristics of a rare form of meningiomas.

AFFILIATIONS

  1. Department of Neurosurgery, Markusovszky University Teaching Hospital, Szombathely
  2. School of Graduate Studies, School of Medicine, University of Pécs, Pécs
  3. Department of Pathology, Markusovszky University Teaching Hospital, Szombathely
  4. Department of Molecular Pathology, Markusovszky University Teaching Hospital, Szombathely

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