Clinical Neuroscience

[Possible involvement of superantigens of the etiology in multiple sclerosis and other autoimmune diseases]

KÁLMÁN Bernadett1, LUBLIN D. Fred2

SEPTEMBER 20, 1993

Clinical Neuroscience - 1993;46(09-10)

[The superantigens are bacterial and viral protein products, which differ from conventional antigens, since they activate and ultimately delete lymphocytes in a T cell receptor Vb chain specific manner. As the activation may involve 30% of the total T cell population, it is possible that autoimmune clones are also included. Restricted heterogeneity of T cells has been described in several autoimmune diseases including multiple sclerosis. Thus, the possible triggering role of superantigens has stimulated new investigations. Although the data implicating superantigens in the etiology of these diseases are indirect, recent experimental results suggest their therapeutic applicability, using the long lasting deletion effect.]

AFFILIATIONS

  1. Országos Ideg- és Elmegyógyászati Intézet, Budapest
  2. Thomas Jefferson University, Philadelphia

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