Részletes keresés

Ideggyógyászati Szemle

1995. MÁRCIUS 01.

THE PRINCIPLES OF GENE THERAPY FOR GENETIC DISEASES OF MUSCLE (DUCHENNE DYSTROPHY), SPINAL MOTOR NEURONS (SPINAL MUSCULAR ATROPHY) AND SCHWANN CELLS (SCHWANNOPATHIES)

GYULA Acsadi, ÁGNES Jani, HANNS Lochmüller, GEORGE Kárpáti

Gene replacement therapy using adenoviral vectors in genetic diseases of the motor unit is a potential treatment modality. ln preclinical experiments, promising results have been obtained by dystrophin minigene replacement in mdx mice. There are several serious problems that remain to be resolved (i. e. immunologically mediated elimination of transduced cells) before this approach can be used in human clinical trials.

HUN 1995;48(3-4)

Ideggyógyászati Szemle

1995. MÁRCIUS 01.

A Free Radical Scenario ln Multiple Sclerosis

BHARANIDHARAN Padmanabhan

Multiple Sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) that has so far eluded auempts to determine it's cause. It could be that there isn't any one cause to determine. And so, as with many other multivariate nonlinear disorders, numerous epidemiological studies have been carried out to help identify possible modifying factors in the disease and the genetic linkages involved, not just to discover the etiology but also to help patients in need.

HUN 1995;48(3-4)