Clinical Neuroscience - 2000;53(3-4 Különszám)

Clinical Neuroscience

MARCH 01, 2000

[Experimental and clinical imaging methods for the examination of blood flow and metabolism of the central nervous system]

BERECZKI Dániel, CSIBA László, GULYÁS Balázs

[The authors review the most important techniques used to image blood flow and metabolism of the central nervous system in animal experiments and clinical studies. A summary of the principles and the history of the methods are given and examples are shown to demonstrate the sensitivity and resolution of different techniques. Of the methods used in animal experiments the authors show examples for regional biochemical imaging based on fluorescence, bioluminescence and color reactions as well as autoradiography. Among the clinical investigations for imaging cerebral blood flow techniques based on dynamic scintigraphy, photon emission and positron emission tomography are summarized. The authors list possibilities for imaging glucose-, oxygen and protein metabolism and regional cerebral blood volume. Examples are shown for the different application areas of clinical imaging, among them receptor studies and clinical pharmacological investigations.]

HUN 2000;53(3-4 Különszám)