Hypertension and nephrology

[The role of juxtaglomerular apparatus in regulation of renal hemodinamics]

ROSIVALL László

OCTOBER 20, 2013

Hypertension and nephrology - 2013;17(03-04)

[The tubuloglomerular feedback mechanism (TGF) is one of the basic processes in the regulation of renal microcirculation. During the activation of TGF the macula densa senses the tubular fluid and ions loads and initiates a rather complex mechanism in juxtaglomerular apparatus resulting in a change of GFR and tubular load. During the activation of TGF there is humoral signaling in the interstitial extraglomerular area. The concentration of the mediator depends on the extraglomerular interstitial fluid movement through the fenestrated endothelium, which is determined by the actual pressures. A new and fast GFR regulation mechanism is described as a consequence.]

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