Hypertension and nephrology

[Facts and misbeliefs regarding thiazides and thiazide-like diuretics]

BENCZÚR Béla1

SEPTEMBER 13, 2021

Hypertension and nephrology - 2021;25(04)

DOI: https://doi.org/10.33668/hn.25.020

[Diuretics are listed in hypertension guidelines as part of first-line treatment options unvariably. A lot of discussion has been directed at side effect profiles and as a result, has created a perhaps disproportionate fear of the metabolic effects and potential increased risk of skin cancer that can be associated with diuretics. Data, however, show that the risk of a clinically meaningful change in laboratory parameters is very low, their carcinogenic potential is not fully proved, whereas the benefits of volume control and natriuresis are high and the reductions in morbidity and mortality are clinically significant. Moreover, several international guidelines have started making a distinction between thiazides (hydrochlorothiazide) and thiazide-like (chlorthalidone, indapamide) diuretics; and some of them now recommend longer acting thiazide-like diuretics. Based on this differentiation chlorthalidone and indapamide may need to be subdivided further into separate classifications. Nevertheless, it’s worth to know that indapamide exists in two formulation with ]

AFFILIATIONS

  1. Tolna Megyei Balassa János Kórház, I. Belgyógyászat (Kardiológia/Nefrológia), Szekszárd

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Hypertension and nephrology

[May measurement month: analysis of the Hungarian results of years 2017 and 2019]

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[Cardiovascular (CV) diseases are not only the leading causes of mortality in Hungary, but also the mortality rate is excessively high compared with the average of European Union, so screening programs identifying subjects with elevated blood pressure (BP) is of utmost importance. May Measurement Month (MMM) is an annual global initiative which began in 2017 aimed at raising awareness of high BP. Hungary, through the Hungarian Society of Hypertension has joined the campaign of MMM from the beginning. The results of years 2017 and 2019 are presented in this paper. ]

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BÓDI Brigitta, FEJES Réka, KARDOS Magdolna, DEÁK György

[Summary – Membranous glomerulopathy (MGP) is the most frequent cause of nephrotic syndrome in adults. It is classified as a primary autoimmune disease or secondary MGP due to malignancies, autoimmune diseases, infections or adverse drug reactions. Here we present two cases of MGP.]

Hypertension and nephrology

[Hypertension-infertility. Can be any connection between them?]

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[Summary – Considering the pathomechanism, the risk factors, as well as the environmental and toxic effects, some associated illnesses, unhealthy life-style habits in the background of hypertension and infertility, significant overlapping can be found. The question arises; does play any role the hypertension in the development of infertility? In this article the author review the connection between the hypertension and infertility. ]

Hypertension and nephrology

[The translation of scientific evidence into arterial hypertension guideline (ESC/ESH Guidelines for the management of arterial hypertension): certainty and uncertainty in decision-making]

KOLLER Ákos, TAKÁCS Johanna

[Clinical practice guidelines summarise the existing knowledge of a given medical field, helping healthcare professionals to make medical conscious medical decisions. Our present study aims to analyse the Arterial Hypertension (AH) Guideline issued by the ESC/ESH to determine what overall certainty it has for making effective decisions.]

Hypertension and nephrology

[The treatment of patients with hypertension and HFpEF. The role of MRA (mineralocorticoid receptor antagonist), ARNI (angiotensin receptor blocker – neprilysin inhibitor), and the SGLT-2 inhibitors ( sodium-glucose-cotransporter-2 inhibitors)]

MASSZI Gabriella

[The prevalence of the symptomatic form of heart failure with preserved ejection fraction (HFpEF) often causes therapeutic problem for physicians. Hypertension is one of the most frequent concomitant illness among many comorbidities. Therefore its treatment, care and monitoring needs special attention, as well. Newer therapeutic options will be reviewed in the light of the results of the studies concerning treatment of HFpEF and high blood pressure.]

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