Clinical Neuroscience

[The effect os levodopa in Parkinson's disease ]

MECHLER Ferenc1, DIÓSZEGHY Péter1, GLAUB Theodóra1, HIDASI Eszter1, JOSE Rosa1

MAY 20, 1996

Clinical Neuroscience - 1996;49(05-06)

[The effect of carbidopa/levodopa on clinical signs and laboratory data was studied in 21 patients with Parkinson's disease during a follow-up period of 7-12 months. The Columbia and Webster scales were used for analysis. The improvement was significant already in the first weeks of the treatment. The drug did not influence the laboratory data and the side effects were found to be insignificant. The changes due to the drug were analysed by electrophysiological methods. Certain peak amplitudes and the area of visually evoked responses increased significantly during the treatment suggesting facilitation in the function of visual pathways. On stimulating the motor system by transcranial and spinal magnetic stimulation, the motor latencies and the duration of silent period showed normalization. ]

AFFILIATIONS

  1. DOTE Ideg- és Elmegyógyászati Klinika, Debrecen

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