Clinical Neuroscience

[The effect os levodopa in Parkinson's disease ]

MECHLER Ferenc1, DIÓSZEGHY Péter1, GLAUB Theodóra1, HIDASI Eszter1, JOSE Rosa1

MAY 20, 1996

Clinical Neuroscience - 1996;49(05-06)

[The effect of carbidopa/levodopa on clinical signs and laboratory data was studied in 21 patients with Parkinson's disease during a follow-up period of 7-12 months. The Columbia and Webster scales were used for analysis. The improvement was significant already in the first weeks of the treatment. The drug did not influence the laboratory data and the side effects were found to be insignificant. The changes due to the drug were analysed by electrophysiological methods. Certain peak amplitudes and the area of visually evoked responses increased significantly during the treatment suggesting facilitation in the function of visual pathways. On stimulating the motor system by transcranial and spinal magnetic stimulation, the motor latencies and the duration of silent period showed normalization. ]


  1. DOTE Ideg- és Elmegyógyászati Klinika, Debrecen



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Clinical Neuroscience

[Somatic defects and pain manifested at adults' drawings of a man]


[The outhor observed that “draw-a-man tests” of mentally retarded or demented adult patients may truly reflect their somatic defects or painful disorders. Drawings of mentally intact patients could also exhibit their somatic illness if it causes pain or the compensating mechanisms are insufficient. A brief discussion is given on the possible mechanisms, in connection with the body-schema.]

Clinical Neuroscience

[Topographic pattern of spike-waves in absence seizures]


[Topography of generalized ictal spike-wave patterns (absence seizures) have been investigated by voltage mapping analysis. The 31 patients investigated in this study belonged to a wide variezy of epileptic syndromes with absence seizures. Previously described different topographic patterns of the spike and the wave components have been confirmed in this study.]

Clinical Neuroscience

[The prognostic relevance of apoptosis in medulloblastoma]


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Clinical Neuroscience

[Thrombolytic therapy in acute ischemic stroke (preliminary report)]

HAFFNER Zsolt, HORVÁTH Erzsébet, HORVÁTH Éva, PAPP Gabriella, EGERVÁRI Ágnes, LIPÓTH Sarolta, CSÁNYI Attila, TUKA Andrea

[Intravenous stretiokinase infusion therapy was performed on four patients in acute occulsive cerebrovascular disease (hemorrhage was rxcluded by CT scan). The thrombolytic therapy was started not later than six hours after the onset of the first symptoms. Kabikinase (1 250 000 IU) was administered in intravenous infudion during two hours. After thrombolysis no prolonged anticoagulant therapy was applied. Improvement of the neurological symptoms was impressive and convincing: in two cases immadiate. Ino one case we could be observed during the treatment (2 hours) nor after it. The possibility of thromolytic therapy in acute occulsiv stroke should be take into consideration. So far as we are aware this is the first time that thromolysis is occulsive stroke according to a protocol like this has been used in Hungary.]

Clinical Neuroscience

[Glaucomatous optic nerve disease]

ÁGNES Boros, JOHN Bryan Fenton, IVAN Bodis-Wollner

[Glaucomatous optic nerve disease (GOND) is the axonal neuropathy of the optic nerve and this diagnosis should enter the differential diagnosis of patients complaining of progressive diminution of vision. A positive family history is one of the major risk factors. Current theories regard the elevation of intractor pressure only a risk factor of GOND, not as its cause. The pathophysiology of ganglion cell dam- age in GOND in some respect parallels processes in other neurodegenerative disease. Current therapy aims at reducing the intraocular pressure and new forms of therapy, to prevent neuronal death are being developed. ]

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Clinical Neuroscience


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Clinical Neuroscience

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