Clinical Neuroscience

Recurrent posterior fossa haemangioblastomas

J. Julow1, K. Bálint2, P. Gortvai3, E. Pásztor2, F. Slowik2

MAY 20, 1994

Clinical Neuroscience - 1994;47(05-06)

We presented reviews of various aspects of posterior fossa haemangioblastomas operated on at the Hungarian National Institute for Neurosurgery and at St. John's Hospital. (2, 3, 4) The present work examines some problems concerning recurrence of these tumours.

AFFILIATIONS

  1. St. John's Hospital, Budapest
  2. National Institute of Neurosurgery Budapest
  3. St. Bartholomew's Hospital London U.K

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Cerebral autoregulation was investigated in the cerebral and cerebellar cortex, and subcortical gray matter (caudate nucleus) of the rat by means of Laser-Doppler flowmetry. As the vascular architecture of the basal ganglia, the cerebral cortex and the cerebellar cortex have substantial geometrical, onto genetical and pathological differences (3), we tested the working hypothesis that autoregulation of the blood supply to these areas may also be different. Laser-Doppler flowmetry has an ideal time resolution, and it enables analysis of flow-pressure curves (1, 2). The dependency of autoregulation on the rate of change in systemic blood pressure (SABP) in all three regions were confirmed. Control of CBF was significantly different in the subcortical gray matter and the neocortex. Interestingly, no autoregulatory capacity of the cerebellar vasculature was found.

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