Clinical Neuroscience

Recurrent posterior fossa haemangioblastomas

J. Julow1, K. Bálint2, P. Gortvai3, E. Pásztor2, F. Slowik2

MAY 20, 1994

Clinical Neuroscience - 1994;47(05-06)

We presented reviews of various aspects of posterior fossa haemangioblastomas operated on at the Hungarian National Institute for Neurosurgery and at St. John's Hospital. (2, 3, 4) The present work examines some problems concerning recurrence of these tumours.

AFFILIATIONS

  1. St. John's Hospital, Budapest
  2. National Institute of Neurosurgery Budapest
  3. St. Bartholomew's Hospital London U.K

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Epidermoid tumours of the posterior fossa

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In opposite of the benign biological behaviour of the posterior fossa epidermoids the operation of these tumours a great challenge for the surgeon both theoretical and surgical point of view. We analysed our 14 operated cases clinico pathologically in this retrospective study.

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Brain stem gliomas are rare, predominantly pediatric tumours. Histologically, they are comparable to adult supratentorial astrocytomas. Most of the pediatric brain stem tumours were classified as low-grade astrocytoma (WHO II), anaplastic astrocytoma (WHO III) or glioblastoma multiforme (GBM, WHO IV). Survival of patients with malignant brain stem gliomas as WHO grade III and IV rarely exceeds more than two years. Recently developed molecular genetic techniques gave new insights in tumour biology. Oncogenes and tumour suppressor genes are genetic alterations which can cause tumorous transformation and furthermore malignant progression. Molecular genetic studies of malignant brain stem gliomas have rarely been investigated. Therefore, we set out to study 12 such tumours clinically and 2 by molecular biological methods.

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Different autoregulatory responses in the cerebellar cortex, neocortex and subcortical gray matter of the rat to systemic hypo- and hypertension

BALÁZS István, BARZÓ Pál, DÓCZI Tamás, PÓRSZÁSZ Róbert, SZOLCSÁNYI János

Cerebral autoregulation was investigated in the cerebral and cerebellar cortex, and subcortical gray matter (caudate nucleus) of the rat by means of Laser-Doppler flowmetry. As the vascular architecture of the basal ganglia, the cerebral cortex and the cerebellar cortex have substantial geometrical, onto genetical and pathological differences (3), we tested the working hypothesis that autoregulation of the blood supply to these areas may also be different. Laser-Doppler flowmetry has an ideal time resolution, and it enables analysis of flow-pressure curves (1, 2). The dependency of autoregulation on the rate of change in systemic blood pressure (SABP) in all three regions were confirmed. Control of CBF was significantly different in the subcortical gray matter and the neocortex. Interestingly, no autoregulatory capacity of the cerebellar vasculature was found.

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