Clinical Neuroscience

[Fibrinogen as a general risk factor in stroke ]

SZIRMAI Imre1, KAMONDI Anita1

MAY 20, 1993

Clinical Neuroscience - 1993;46(05-06)

[Fibrinogen and other laboratory variables of 348 patients with various types of stroke were statistically analysed in the acute, subacute and chronic stage of the disease. Seventy two patients with non-vascular disease served as control. The actual level of plasma fibrinogen in cerebrovascular patients was attributed to the following factors: 1. presence of atherosclerotic plaques in extra and intracranial arteries, 2. the time lag between the onset of stroke and laboratory testing, 3. degre of post stroke mobility of the patients. Initial level of fibrinogen is a predictive value of death both in hemorrhagic and ischemic patients. The highest plasma concentration of fibrinogen was found in the atherothrombotic stroke group, in which was a significant negative correlation between the plasma fibrinogen and high density lipoprotein level. It was concluded that fibrinogen is a risk factor in cerebrovascular diseases.]

AFFILIATIONS

  1. Pécsi Orvostudományi Egyetem Neurológiai Klinika, Pécs

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