Clinical Neuroscience - 1985;38(02)

Clinical Neuroscience

FEBRUARY 01, 1985

[Neuropsychiatric manifestations of systemic lupus erythematosus: clinical observations]

TEMESVÁRI Péter

[The author reports on a study of 59 patients with systemic lupus erythematosus, of whom 37 patients (63%) had a total of 92 neuropsychiatric episodes. The most common neurological manifestations were: depression; headache; peripheral neuropathy; memory impairment; chronic psychosis; epilepsy; acute organic prsychosyndrome; organic goitre; transient ischaemic attack. Neuropsychiatric phenomena are usually reversible, fluctuating; polymorphic and variable; multilocular, sometimes forming bizarre combinations; associated with signs of systemic lupus erythematosus activity; latent neurological symptoms are common. Among the complementary investigations, EEG and psychological examination gave the most positive results, CSF examination, CT and brain scintigraphy the most negative results. Neuropsychiatric phenomena are not a poor prognosis and corticosteroids are still indispensable in their treatment. Clinical and and pathological findings, the author outlines recent theories on the pathomechanism of the neuropsychiatric phenomena of systemic lupus erythematosus.]

HUN 1985;38(02)

Clinical Neuroscience

FEBRUARY 01, 1985

[Prognostic significance of subjective response and early effect in neuroleptic treatment]

DR. BARTKÓ György, DR. BÉKÉSY Marian

[The authors investigated the subjective response to a test dose of Haloperidol in schizophrenic patients with acute psychotic states and its value for short-term prognosis of treatment. Syntonic response suggests a good treatment prognosis, dysphoric response suggests a poor treatment prognosis. It was found that with further treatment with the same drug, the early antipsychotic effect already in the first 5 days of treatment is superior to the short-term reliably predicted short-term outcome and this was particularly true under standardized conditions under standardised conditions.]

HUN 1985;38(02)

Clinical Neuroscience

FEBRUARY 01, 1985

["Asymptomatic" stenosis of the internal carotid artery in the neck]

DR. BODOSI Mihály, DR. HORVÁTH Zoltán, DR. MÉREI F. Tibor, DR. STEFANITS János

[In parallel with the number of angiograms, the detection of "asymptomatic carotid stenosis" has become more common. So is the question of surgical correction is increasingly awaiting a decision. Their position is based on clinical experience and and literature, they present their position in four different contexts.]

HUN 1985;38(02)

Clinical Neuroscience

FEBRUARY 01, 1985

[Our clinical experience with a selective dopamine antagonist (Tiapride)]

DR. LIPCSEY Attila, DR. NAGY Endre

[The authors report on the treatment of 33 patients with Triapride. They found that the analgesic effect of the drug was not significant: the sedative effect in predelirium and delirium was also less convincing, although other factors, such as the low number of cases and the low dose, may have played a role. Tiapride was found to be very effective - and much more beneficial than other agents - as a new type of selective D2 receptor antagonist in extrapyramidal hyperkinesias, especially in the treatment of tardive dyskinesia associated with neuroleptic treatment and in Gilles de la Tourette syndrome.]

HUN 1985;38(02)

Clinical Neuroscience

FEBRUARY 01, 1985

[Lithium transport pathways in the nerve cell membrane I. Sodium-lithium countertransport]

DR. JANKA Zoltán, DR. SZENTISTVÁNYI István

[The authors have investigated the membrane transport of lithium ion in neuronal cultures from cerebral tissue, with results in the prevention and therapy of affective psychoses. Reducing the extracellular sodium concentration increased the lithium uptake rate of the cells and reduced the rate of lithium shedding. However, the uptake of sodium by nerve cells was reduced by increasing the extracellular lithium concentration and increased by the presence of intracellular lithium. A saturating component was detected in the external lithium concentration-dependence of cellular lithium uptake. The equilibrium cell/medium lithium distribution was established in about 30 min and did not change for days in neuronal cultures. The equilibrium intra:extracellular lithium concentration ratio was less than 1. The experimental results suggest that, like red blood cells, a formally sodium-lithium exchange countertransport system operates in the membrane of brain neurons, which may be important in the mechanism of the therapeutic effect of lithium under in vivo conditions during maintenance lithium treatment and in the regulation of cerebral lithium homeostasis and detoxification.]

HUN 1985;38(02)