Clinical Neuroscience - 1969;22(06)

Clinical Neuroscience

JUNE 01, 1969

[Genetically suspected systemic diseases of the cerebellum]

HORÁNYI Béla

[Author summarizes the genetically suspected systemic diseases of the cerebellum.]

HUN 1969;22(06)

Clinical Neuroscience

JUNE 01, 1969

[Genetics and psychiatric approach ]

SZABÓ Gábor

[Understanding and altering the structure of DNA, the material responsible for heredity, is a realistic goal of today's research, as is understanding and influencing its regulation. And although healing and conscious influencing are still effective in only a small number of cases, and although the importance of genetic work seems to be justified only by the perspective and the pure joy of learning, the need and possibility of individual help and advice is itself sufficient impetus to increase the teaching and cultivation of genetics in our medical training and in our medical and research practice. ]

HUN 1969;22(06)

Clinical Neuroscience

JUNE 01, 1969

[Effect of diazepam (Valium and Seduxen) on the generalized spike-wave EEG mechanism]

HALÁSZ Péter, HIDASI József

[In six patients with petit mal and petit mal varians epilepsy with spike-wave mechanisms, diazepam initially prevented both clinical and EEG paroxysms, then the spike components of the spike-wave pattern increased, the slow waves decreased; the pattern changed to repetitive rapid discharge and clinically grand mal seizures occurred; however, the antiepileptic effect of the higher dose given i.v. was preserved. Barbiturate promoted the conversion of petit mal to grand mal. To explain the observed phenomenon, it was hypothesized that diazepam at higher doses depresses both inhibitory and facilitatory cortical synapses, whereas at lower doses, when administered continuously, it mainly paralyses only inhibitory cortical synapses. As a practical therapeutic conclusion, we consider that in petit mal and petit mal variant epilepsy and in all cases where there is a tendency to generalized repetitive rapid discharges, chronic administration of diazepam is contraindicated.]

HUN 1969;22(06)