Hypertension and nephrology

[Cilostazol improves quality of life and lower limb functional capacity in lower extremity arterial disease regardless of age and gender – new results of the SHort-tERm cIlostazol eFFicacy and quality of life (SHERIFF) study]

FARKAS Katalin1,2, KOLOSSVÁRY Endre 1,2, JÁRAI Zoltán2,3

APRIL 22, 2022

Hypertension and nephrology - 2022;26(02)

DOI: https://doi.org/10.33668/hn.26.008

[Intermittent claudication has a significant negative impact on the patients’ quality of life. Revascularization procedures and noninvasive medical therapie scan improve walking capacity. Cilostazol has IA recommendation for the treatment of intermittent claudication (IC). The aim of this study was to evaluate the effect of three-month cilostazol treatment on the health related quality of life and on the lower limb functional capacity in women (F) and men (M), in patients under 65 years of age (Y) and among patients 65 years of age or older (O) with intermittent claudication in the clinical practice. The study was a multicenter, non-interventional trial, 812 lower extremity arterial disease (LEAD) patients (Fontaine II stage, mean age: 67.17 years, male/female: 58.25/41.75%, 506 patients aged ≥65 years) were enrolled, who received cilostazol (50 or 100 mg b.i.d.) for three months. Quality of life was evaluated with the EQ- 5D-3L questionnaire, functional capacity with the WELCH questionnaire. Walking distances, ankle-brachial index were measured at baseline and after 3-month. Upon conclusion of the study, the EQ-5D index improved (baseline: F [female] –0.49±0.23, M (male –0.44±0.22, Y (age <65 years) –0.45±0.21, O (age ≥65 years) –0.47±0.23; 3rd month: –0.27±0.18, –0.25±0.18, –0.25±0.18, –0.26±0.18; respectively, p<0.0001) and there was a significant increase in the WELCH score as well (baseline: F 18±13, M 20±14, Y 21±14, O 18±13; 3rd month: 31±18, 32±18, 32±19, 31±17; respectively, p<0.0001). Both pain-free and maximal walking distance increased: F 60.94%, (median: +50.26%), 49.57%, (median: + 42.86%), M 50.22%, (median: +50%), 37.7%, (median: + 33,33 %), Y 54,35 %, (median: + 56,2%), 36.78%, (median: +42.86%), O 54.62%, (median: +50%), 46.29% (median: +33.33%); respectively (p<0.001). Three months of cilostazol treatment improved quality of life and lower limb functional capacity in claudicant patients regardless of age and gender. The WELCH questionnaire is a useful tool in clinical practice for the evaluation of intermittent claudication treatment.]


  1. Dél-budai Centrumkórház Szent Imre Egyetemi Oktatókórház, Angiológia
  2. Semmelweis Egyetem, Angiológia Tanszéki Csoport
  3. Dél-budai Centrumkórház Szent Imre Egyetemi Oktatókórház, Kardiológia



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