Clinical Neuroscience

[Intracranial metastasis]

GOMBI Róza1, HULLAY József2

OCTOBER 01, 1960

Clinical Neuroscience - 1960;13(10)

[The authors report clinical, surgical and pathological evaluation of 35 operated brain metastases. In their material, metastasis represented 9% of brain tumour cases. Postoperative mortality was 17%. Postoperatively, the mean survival of patients was 8 months and the overall survival was 51%. Based on the surgical and pathological picture, a percutaneous tumor cell embolus metastasis mechanism is considered likely and suggests that cortico-subcortical cancer metastases removed by radical resection do not recur locally. Most of these cases were cancer metastases. In their dissected cases, multiple brain metastases were always found. In terms of localisation, frontal metastases (42%) and primary tumours located in the lung (42%) were the most common. Regarding the question of surgical indications, it is pointed out that the principle that only solitary metastases should be operated on is not feasible in practice, due to current diagnostic capabilities and for reasons that, apart from absolute infaust cases, argue in favour of surgery in cases of multiple metastases. ]

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  1. Debreceni Orvostudományi Egyetem Ideg-Elmeklinikája
  2. Debreceni Orvostudományi Egyetem Ideg-Elmeklinika

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[Data on female alcoholism]

BÖSZÖRMÉNYI Zoltán, SRÁGLI Gyula

[The Communication looks at the increasing prevalence of alcoholism among women worldwide, according to statistical data ; it presents the main data available to explain this phenomenon. The authors have derived their own findings from a comparative study of the histories of 303 female patients discharged from the National Institute of Neurology and Mental Health between 1 January 1954 and 31 December 1959, and of 150 male alcoholics from the same period, used as a control. They found a smaller increase in the number of female alcoholics, and that the majority of women are withdrawn much earlier than men, with a higher incidence of alcoholism in their families. The majority of women drinkers are only engaged in domestic or other simple-primitive work. Only 15.3% of women and 42% of men were considered to be normal drinkers, with the latter making much less effort to explain their drinking. Women are more withdrawn in group psychotherapy sessions, but seem to need this treatment more than men. The authors present three illustrative case reports. They conclude that the rise in the number of women alcoholics should not be accepted as a necessary consequence of the neutralisation process (Bürger-Prinz), but should be combated by adequate education.]

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[Experimental eosinophil number changes in response to a new iminodibenzyl derivative]

ANTAL János

[We investigated the effect of a new iminodibenzyl derivative, Tofranil, on the eosinophil count in circulating blood and the eosinopenia reactivity. We found that at a dose of 0.1-0.5 mg/100 g, the eosinophil cell count almost doubled after a weekly daily dose. At higher doses (1-5 mg/100 g), a single injection can maintain high eosinophil levels after one week. Also at a high dose (1-5 mg/100 g), eosinophilia develops as early as 4 hours after injection. Thyroidectomy abolishes the eosinophilic effect of Tofranil acut. High dose given once daily (1--5 mg/100 g) or low dose given daily for a week (0.1-0.5 mg/100 g) prevents eosinophilic reaction to 50 pg epinephrine administration 4 hours after onset. Inhibition of eosinopenia was only minor when administered as a single small dose or when Tofranil was given one hour before epinephrine. It is assumed that Tofranil induces complex neuroendocrinological effects in rats.]

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Late simultaneous carcinomatous meningitis, temporal bone infiltrating macro-metastasis and disseminated multi-organ micro-metastases presenting with mono-symptomatic vertigo – a clinico-pathological case reporT

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Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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