Clinical Neuroscience

2nd Congress of the Hungarian Section of the International Anti-Epilepsy League

JULY 20, 1996

Clinical Neuroscience - 1996;49(07-08)

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Clinical Neuroscience

37th Congress of the Hungarian Society of EEG and Clinical Neurophysiology

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[Topography and Frequency Analysis of EEG and Triggered Responses]

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[Quality of life in children and adolescents with epilepsy]

NIKL János

[The quality of life issues in 95 patients with mild or moderate epilepsy between the ages 7-18 were evalvated by a questionnaire. The author analysed the emotional, interpersonal, vocational adjustments; adjustments to seizures; family backgrounds, financial status, medical management and overall psychosocial functioning. The data indicated a relatively high incidence of psychosocial problems among epileptics. The reason for these changes are multifactorial they include biological, psychic and social variables. However the rate of dysfunctions in childhood seems to be lower than expected. The higher rate observed in the case of adults suggest that psychosocial disturbances become more violent later on, they may culminate in a mid-life crisis. In order to prevent such a situation, some tasks regarding the biological conditions, a teaching-programme on epilepsy, choice of career, getting a driving licence and an alternative model for the medical management are proposed to be carried out.]

Clinical Neuroscience

[Changes in prolactin and cortisol levels after partial epileptic seizures]

KALÓCZKAI Andrea, HALÁSZ Péter

[Within the framework of presurgical evaluation 14 therapy resistant partial epileptic patients were studied. The prolactin and cortisol serum levels were measured in 15 partial seizures 15, 30 and 60 minutes after the beginning of seizures. Based on the localization of the siezure start on the EEG, ictal, interictal SPECT, MRI and neuropsychological findings the patients were devided into two groups: temporal lobe epilepsy (TLE) and extratemporal epilepsy (ETE). The hormone level measurement was carried out during video-EEG monitoring. In the 11 TLE patients prolactin level increase was found in all cases after the seizures either in the 15th or in the 30th minute samples. In the 4 ETE patients similar increase was found only in 1 patient. Cortisol level increase was found in 10 of the 11 TLE patients and in 2 of the 4 ETE patients. Our findings support the view according which prolactin and cortisol increases occur after seizures involving the temporo-limbic structures. Hormone level peaks are not obligatory consequences of partial epileptic seizures therefore there is no real point in differentiating between epileptic and pseudoepileptic seizures. ]

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[Hungarian Society of Neurologists and Mental Physicians SZOTE neurological round table]

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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