Lege Artis Medicinae

[Frequency and risk factors of “de novo” tumors after kidney transplantation ]

BORDA Bernadett1, HÓDI Zoltán1, SZEDERKÉNYI Edit1, OTTLAKÁN Aurél1, SEREGÉLY Edit1, LÁZÁR György1, KERESZTES Csilla2, VIRÁG Katalin3

SEPTEMBER 30, 2020

Lege Artis Medicinae - 2020;30(08-09)

DOI: https://doi.org/10.33616/lam.30.030

[After kidney transplantation, the administration of immunosuppressive therapy not only renders the patient susceptible to infections, but it may also damage the function of tumor cell recognition and elimination. Our study was performed at the Department of Surgery, University of Szeged. After establishing the inclusion criteria, 570 patients were involved in the study. We examined the age, sex, immunosuppressive therapy of the patients, and searched for the rela­tionship between the different immunosuppressive agents and the type of the tumor. In 81 cases, de novo cancer was diagnosed. Among patients treated with cyclosporin and tacrolimus there was no significant difference in the mean age (p = 0.734) and body mass index (p = 0.543). There was no significant difference in graft function between the two groups of patients (Tac vs Cyc; 44 vs 20). Related to the time passed since the trans­plantation to diagnosing the tumors the earliest were prostate and cervix cancers however without significant difference. Skin cancers are the most frequent followed by post-transplant lym­pho­prolife­ra­tive diseases. The increasing risk of developing tumors is mainly due to immunosuppressive therapy. ]

AFFILIATIONS

  1. Szegedi Tudományegyetem, Általános Orvostudományi Kar, Sebészeti Klinika, Szeged
  2. Szegedi Tudományegyetem, Általános Orvostudományi Kar, Orvosi Szaknyelvi Kommunikációs és Fordítóképzô Csoport
  3. Szegedi Tudományegyetem, Orvosi Fizika és Orvosi Informatikai Intézet

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