Lege Artis Medicinae

[Creation of fingers]

KOVÁCS Sándor

DECEMBER 19, 2023

Lege Artis Medicinae - 2023;33(12)

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Further articles in this publication

Lege Artis Medicinae

[Changing of the guard – Interview with the new and outgoing president of the MOK, with Péter Álmos and Gyula Kincses]

KAPÓCS Gábor

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Lege Artis Medicinae

[ Two undeservedly undervalued stars of Hungarian opera]

WINKLER Gábor

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Lege Artis Medicinae

[Whose life is it anyway? – Inevitable Christmas reflexions]

KAPÓCS Gábor

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Lege Artis Medicinae

[The role of brain neural networks in the developing dementia: our research methods from optogenetics to artificial intelligence]

HANGYA Balázs

[In the Laboratory of Systems Neuroscience of the Institute of Experimental Medicine, our main objective is the better understanding of the brain mechanisms of cognitive functions. We investigate the nervous system basis of learning, memory, attention and decision-making not only in normal conditions but also in pathological ones, especially concerning the neurodegenerative dementias such as Alzheimer’s and Parkinson’s dis­ease. 



Our main profile is conducting animal studies, but we carry out hu­man research too in collaboration with clinical partners. We analyse multichannel, i.e. multidimensional electrophysiological signals using both classical and modern statistical methods and new and powerful machine learning algorithms. 



This study presents the activity of our team, while focusing on artificial intelligence app­lications.

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Lege Artis Medicinae

[The impact of end-of-life spirituality on the quality of life – Scoping review]

SIPÔCZ Diána Gizella, TÓTH Pál Péter, HEGEDÛS Katalin

[By nearing death, patients face more difficulties as they confront with their own transience, with ultimate loss of their life. Among all multidimensional needs of dying people, end-of-life spirituality has received increasing attention in scientific research during the recent decades. The aim of this study is mapping the impact of end-of-life spirituality on the quality of life as reflected in the relevant literature, and to present the scientifically significant key definitions and measurement options by their difficulties. 

Review of English-language papers published after 2017, searched in PubMed and PsycINFO databases using the PRISMA-ScR protocol, with scoping re­view method, that investigate the impact of end-of-life spirituality. In addition, there was also supervised a review of the authors’ unpublished literature review on the same topic conducted in 2016.

A total of 59 articles were identified by the database searches. Only 2 of the previous review papers were applied here. Each reviewed paper was generally positive about the impact of end-of-life spirituality on the quality of life. Two papers mention a possible negative effect of spirituality on certain factors of the quality of life.

 Semantic concerns and measurement difficulties of this topic cause discrepancies in evaluating the study re­sults. Further research of practical spirituality should be valuable to clarify which components may cause negative coping experience in the patients.]

All articles in the issue

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[History of the Founding of the World Health Organization]

KOCZKÁS Vivien

[On the occasion of the 75th anniversary of the founding of the World Health Organization, it is time to examine the circumstances of its creation. Based on sources from contemporary articles, the events present the story of the merger of several smaller national health organizations into one, which formed the World Health Organization known and operating today, the WHO.]

Clinical Neuroscience

Median to ulnar nerve comparison on diagnosis of carpal tunnel syndrome in patients with diabetic polyneuropathy – A neurophysiological study

MURAT ALEMDAR

To analyze the utility of median nerve (MN) to ulnar nerve (UN) comparative parameters on the diagnosis of carpal tunnel syndrome (CTS) in diabetic patients with distal symmetrical sensorimotor polyneuropathy (DSMPNP).

Clinical Neuroscience

Patient with recurrent neuralgic amyotrophy; right brachial plexitis and left posterior interosseous neuropathy

ÖZENÇ Betül , IŞIK Kübra , TAN Ersin , ODABAŞI Zeki

Neuralgic amyotrophy (NA), also known as Parsonage-Turner syndrome or idiopathic brachial plexopathy, is a multifocal inflammatory neuropathy that usually affects the upper limbs. The classic picture is a patient with acute onset of asymmetric upper extremity symptoms, excruciating pain, rapid onset of multifocal paresis often involving winged scapula, and a monophasic course of the disease.

Clinical Neuroscience

[Association of upper extremity anthropometry and subcutaneus adipose tissue with carpal tunnel syndrome]

DAROL Sarica Elif, ÇİÇEKLİ Esen , SAYAN Saadet , KOTAN Dilcan , ALEMDAR Murat

[Body mass index (BMI) is positively correlated with the frequency of carpal tunnel syndrome (CTS). However, there are different types of obesity, and the localization of adipose tissue differs between the genders. In this study, we purposed to investigate whether there was an association between the amount of local adipose tissue thickness and anthropometry in upper extremity with the presence and/or electrophysiological severity of CTS on both genders. ]

Clinical Neuroscience

[Multiple ischemic stroke in Osler-Rendu-Weber disease]

SALAMON András, FARAGÓ Péter, NÉMETH Viola Luca, SZÉPFALUSI Noémi, HORVÁTH Emese, VASS Andrea, BERECZKY Zsuzsanna, TAJTI János, VÉCSEI László, KLIVÉNYI Péter, ZÁDORI Dénes

[Hereditary hemorrhagic teleangiectasia (HHT, Osler-Rendu-Weber disease) is an autosomal dominantly inherited disorder caused by the mutation of several possible genes and characterized by malformations of the arteriovenous system in multiple organs. The clinical diagnosis is based on the Curaçao criteria ((1) spontaneous, recurrent epistaxis; (2) teleangiectasias in characteristic sites (lips, oral cavity, nose, fingers); (3) visceral lesions (gastrointestinal, pulmonary, cerebral, spinal); (4) affected first degree relative). The aim of this study is to present the first genetically confirmed Hungarian case of hereditary hemorrhagic teleangiectasia with multiple ischemic strokes. Our 70-year-old woman has been suffering from severe epistaxis since her childhood and presented gastrointestinal bleeding during her adulthood as well. The characteristic skin lesions developed in the 5th decade of life. She was admitted to our department with loss of consciousness and fluctuating speech and swallowing problems. MRI of the brain supplemented with angiography revealed multiple arteriovenous malformations and multiple subacute ischemic lesions. The EEG demonstrated slowing of electric activity in the left frontal lobe. The neuropsychological assessment showed deficits in anterograde memory and executive functions. The diagnostic work-up for other characteristic alterations identified an arteriovenous malformation in the left lung. The genetic analysis demonstrated a heterozygous mutation in the 7th exon of the ENG gene at position 834 resulting in a thymine duplication and an early stop codon by a frame shift. The present case is largely similar to those already described in literature and draws the attention to the importance of multidisciplinary collaboration in the care of HHT patients.]