Clinical Neuroscience

[Use of Librium in child psychiatry]

KISS Mária1, KISZEL Katalin1

JULY 01, 1967

Clinical Neuroscience - 1967;20(07)

[Based on 60 cases treated in our child psychiatry unit, and in line with what is known from the literature, we have found that Librium is indeed an effective agent in some cases. It should be given primarily for neurotic symptoms. In obsessive-compulsive neurosis, it has proved more effective than any other drug known to date. In psychosis and in behavioural disorders of organic origin, such as oligophrenia and encephalopathy, it does not seem to be effective enough. Its anticonvulsant action has not been satisfactory, but since it does not provoke seizures at low doses, it is excellent for secondary complaints of neurotic origin in epileptics. ]


  1. Országos Ideg-és Elmegyógyintézet Gyermekpsychiatriai Osztály



Further articles in this publication

Clinical Neuroscience

[The problems of angiographic diagnosis in relation to retrograde vertebral circulation]


[Detailed angiographic evidence is provided of the retrograde vertebral circulation with respect to the possibility of a possibility of a sham,,subclavian steal" syndrome is discussed. It is emphasized that elective vertebral arteriography may also normally frequently fill the reciprocal vertebral artery retrogradely. The cause of this must be sought primarily in mechanical factors. By analyzing the angiograms of a patient with true and one with apparent "subclavian steal" syndrome, it is concluded that in case of atypical clinical symptoms or lack of angiographic evidence, one must always think of the apparent "subclavian steal'' syndrome. The differentiation of the two syndromes is only possible by serial aortography, with the help of the Gidlund syringe from the brachial artery or, in the case of occlusion of the subclavian artery, from the common carotid artery. carotis communis.]

Clinical Neuroscience

[An interesting case of a family with progressive dystrophia musculorum with dominant inheritance]


[The author presented a case of a family with autosomal dominant inheritance of shoulder girdle typos with DMP, which is different from the average in several respects. Finally, some hereditary literature on this type of DMP was presented. ]

Clinical Neuroscience

[Indicative guidelines and methodological dilemmas in the treatment of "alcoholism'']


[My report in issue 17 of the Medical Journal of 1961 (102: 769-776) summarized the experiments in the treatment of chronic alcoholism with drugs. It dealt with the expected therapeutic results, side-effects, contra-indications and complications on the basis of literature data and our own 580 case histories. The latter have been discussed in detail elsewhere (Medical Education, 37.103-119, 1962) in connection with our analysis of 33 cases of antaethyl-psychosis and alcohol withdrawal syndrome. The same applies to the socio-psychological interactions modifying the intrinsic effects of drug treatments (Psychological Studies, VII: 295-302, 1965). We must now deal with the general guidelines and methodological dilemmas of active withdrawal treatments from the point of view of a therapeutic plan aimed at resolving the pluricausal alcoholism syndromes. I would like to emphasise the latter with particular emphasis, because rejecting them could lead to fundamental errors of approach and practice, i.e. the notion that alcoholism is a monocausal disease entity and that this erroneous and even harmful view results in a barren effort to provide uniform, routine care for 'alcoholics'. ]

Clinical Neuroscience

[Asymptomatic skull-base destructios]


[Authors describe two patients in whom extensive skull base destruction was detected. No syndromes of cerebral nerve injury, as expected from the location of the destructios, were observed in these patients. Possible reasons for the absence of symptoms are discussed. ]

Clinical Neuroscience

[Data on some relationships between blood and CSF sugar levels ]


[In 404 cases, the ratio of sugar content in blood to CSF was tested. Our experience shows that in some diseases the blood glucose/liquid glucose ratio (V/L Q) deviates significantly from the normal value of 1.5. In our opinion, this deviation is due to increased sugar consumption of nerve tissue in spinal processes and altered function of the choroid plexus in brain processes. Significantly altered V/L Q can be used in the differential diagnosis of radiculitis, radiculopathy, spinal tumour.]

All articles in the issue

Related contents

Clinical Neuroscience

Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

NÉMETH Klára Zsófia, SZÛCS Anna , VITRAI József , JUHÁSZ Dóra , NÉMETH Pál János , HOLLÓ András

We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

Clinical Neuroscience

Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias


In aging societies, the morbidity and mortality of dementia is increasing at a significant rate, thereby imposing burden on healthcare, economy and the society as well. Patients’ and caregivers’ quality of life and life expectancy are greatly determined by the early diagnosis and the initiation of available symptomatic treatments. Cholinesterase inhibitors and memantine have been the cornerstones of Alzheimer’s therapy for approximately two decades and over the years, more and more experience has been gained on their use in non-Alzheimer’s dementias too. The aim of our work was to provide a comprehensive summary about the use of cholinesterase inhibitors and memantine for the treatment of Alzheimer’s and non-Alzheimers’s dementias.

Lege Artis Medicinae

[Thiazide- or thiazide-like diuretics should be used in the treatment of patients with hypertension? Particularities of the situation in Hungary]


[Diuretics have remained the cornerstone of the antihypertensive treatment since their widespreading in the 1960s. According to the 2018 ESC/ESH Guidelines for the management of arterial hypertension, in the absence of evidence from direct comparator trials and recognizing that many of the approved single-pill combinations are based on hydrochlorothiazide, this drug and thiazide-like indapamide can be considered suitable antihypertensive agents. In the 2018 Hungarian guidelines indapamide is named as the most efficacious diuretic in the treatment of patients with hypertension. The aim of the publication is redefining thiazide- and thiazide-like diuretic use in the treatment of hypertensive patients, with particular attention to presently available hydrochlorothia­zide and indapamide, and their combination drugs in Hungary.]

Clinical Neuroscience

A cross-sectional study on the quality of life in migraine and medication overuse headache in a Hungarian sample: understanding the effect of headache characteristics

MAGYAR Máté , KÖKÖNYEI Gyöngyi , BAKSA Dániel, GALAMBOS Attila, ÉDES Edit Andrea , SZABÓ Edina , KOCSEL Natália , GECSE Kinga , DOBOS Dóra , GYÜRE Tamás , JUHÁSZ Gabriella , ERTSEY Csaba

Previous studies using generic and disease specific instruments showed that both migraine and medication overuse headache are associated with lower health-related quality of life (HRQoL). The aim of our study was to assess HRQoL differences in migraineurs and in patients with MOH and to examine how headache characteristics such as years with headache, aura symptoms, triptan use, headache pain severity and headache frequency are related to HRQoL. In this cross-sectional study 334 participants were examined (248 were recruited from a tertiary headache centre and 86 via advertisements). The Comp­rehensive Headache-related Quality of life Questionnaire (CHQQ) was used to measure the participants’ HRQoL. Data showed normal distribution, therefore beside Chi-squared test parametric tests (e.g. independent samples t-test) were used with a two-tailed p<0.05 threshold. Linear regression models were used to determine the independent effects of sex, age, recruitment method, headache type (migraine vs. MOH) and headache characteristics (presence of aura symptoms, years with headache, headache pain severity, headache frequency and triptan use) separately for each domain and for the total score of CHQQ. Significance threshold was adopted to p0.0125 (0.05/4) to correct for multiple testing and avoid Type I error. Independent samples t-tests showed that patients with MOH had significantly lower scores on all CHQQ domains than migraineurs, except on the social subscale. Results of a series of regression analyses showed that triptan use was inversely related to all the domains of HRQoL after correction for multiple testing (p<0.0125). In addition, headache pain severity was associated with lower physical (p=0.001) and total scores (p=0.002) on CHQQ subscales. Based on the results, different headache characteristics (but not the headache type, namely migraine or MOH) were associated with lower levels of HRQoL in patients with headache. Determining which factors play significant role in the deterioration of HRQoL is important to adequately manage different patient populations and to guide public health policies regarding health service utilization and health-care costs.

Journal of Nursing Theory and Practice

[Assessing Nurses’ Knowledge of Surgical Wound Care, Complications and Knowledge of Bandages]


[Aim of our research was to assess the knowledge of nurses working in surgical departments about surgical wound treatment, phases of wound healing, its complications, and intelligent bandages. Our quantitative, cross-sectional, descriptive examination was carried out in a hospital in Transdanubia with non-random, expert sampling and a self-made questionnaire. Our target group was nurses working in the surgical departments of the hospital (N=85). During the data analysis, the descriptive statistical methods of MS Office Excel 2016 software were calculated: mean, standard deviation, frequency. A χ2-test was used to examine the relationship between variables (p <0.05). Knowledge of bandages was not affected by educational attainment (p>0.05). Those who perform wound care in their daily work have more knowledge about the wound treatment sequence of the wounds that are primarily healing, as well as about intelligent dressings (p<0.1). For the classes, there was a significance for the recognition of complicated wounds, knowledge of the benefit of the absorbable suture and the use of analgesic procedures (p<0.001). In the interests of patient safety, nurses’ knowledge of wound treatment needs to be continuously improved. It is necessary to provide an accessible source of information and further training.]