Clinical Neuroscience

[The role of the nervous system in the action of drugs and toxins, Continued]

OBÁL Ferenc1

JUNE 28, 1954

Clinical Neuroscience - 1954;7(03)

[From the conditional reflexes built up in response to various offensive drugs, it can be seen that the outcome of the reflex is determined by the cortical involvement in the process of association. In the case of drugs and poisons that attack the cortex and in which the cortex is actively involved in the creation of the change produced by the drug, the result of the conditioned reflex is the same as the pharmacological effect of the drug. For agents acting in deeper neural areas or in peripheral organs, the result of the conditioned reflex is the reverse of the pharmacological effect of the agent, due to the balancing action of the cerebral cortex. The cerebral cortex plays an important role in determining the body's sensitivity to drugs, because the conditioned reflex that is produced, by its very nature, increases or decreases its sensitivity to drugs and poisons. The conditioned reflexes built up in response to drugs and poisons are subject to the laws of inhibition in the same way as other similar neural processes. ]

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  1. Marosvásárhelyi Orvostudományi és Gyógyszerészeti Felsőoktatási Intézet Élettani, Kórélettani, valamint Gyógyszertani Laboratóriuma

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Clinical Neuroscience

[Behaviour of eosinophil cell counts in schizophrenia cases after different shock treatments]

VARGHA Miklós, TASS Gyula, HUSZÁK István

[1. In 21 cases (75%) of the 28 cases of schizophrenia in the processus stage, the circulating absolut eo. number was found to be lower than normal. 2. In different manifestations of schizophrenia (catatonic hebphren paranoid, etc.), they show uniform behavior. In some patients, electroconvulsion, insulin, etc. under the influence of abnormal reactios types such as rigid non-responsive and ataxic types. Both types of pathological reactions occur in all forms of schizophrenia and were found in 25 (90%) of the 28 cases. 3. In old defect cases, a higher number of normal cell numbers and a normal response to exercise were obtained. In the majority of the 27 old defect, partly post-leukotomy schizophrenic cases, a normal cell count (73%) and a normal response were obtained. According to our studies, even after the administration of high doses of vitamin C, the initial eo. number and eo. reaction becomes normal. We found a parallel between the change in eo. number and the changes in the mental state, i.e. with the improvement of the disease symptoms in the initial eo. cell count increased with a normal response to exercise occurred. Eo based on leukotomy and conditional reflex mechanism. eo. number reaction refers to the importance of the cortex and through it the environment.]

Clinical Neuroscience

[A case of meningioma with supra-infratentorial extent]

PÁSZTOR Emil

[The author describes a case of a surgically resolved meningioma located in the supra- and infratentorial space. The tumour was mostly located infratentorially and grew laterally over the tentorium. The 46-year-old woman underwent surgery in two sessions. After surgery, there was rapid clinical improvement. The interesting aspect of this case is the location of the tumour and its surgical resolution.]

Clinical Neuroscience

[Lectures and presentations of scientific meetings]

[A short summary of 8 scientific lectures.]

Clinical Neuroscience

[Soviet Bibliography]

[The contents of issue 2 of the Journal of nevropatologii i psihiatrii 1954 The contents of the "Zurnal Nevropatologii i psihiatrii imenyi S. S. Korsakov", issue 3, 4 1954 Contents of issue I. II. of Voproszi Nejrohirurgii 1954]

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Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

NÉMETH Klára Zsófia, SZÛCS Anna , VITRAI József , JUHÁSZ Dóra , NÉMETH Pál János , HOLLÓ András

We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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CSÁBI Eszter, ZÁMBÓ Ágnes, PROKECZ Lídia

[A growing body of evidence suggests that sleep plays an essential role in the consolidation of different memory systems, but less is known about the beneficial effect of sleep on relational memory processes and the recognition of emotional facial expressions, however, it is a fundamental cognitive skill in human everyday life. Thus, the study aims to investigate the effect of timing of learning and the role of sleep in relational memory processes. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. Our results suggest that the timing of learning and sleep plays an important role in the stabilizing process of memory representation to resist against forgetting.]