Clinical Neuroscience

Subgroups of brain stem tumors in childhood

PARAICZ Ervin, VAJDA János, CZIRJÁK Sándor, TÓTH Katalin

MAY 20, 1994

Clinical Neuroscience - 1994;47(05-06)

Neuroimaging (MR, CT) and surgical (microsurgery, CUSA, laser) techniques have revolutionised the neurosurgeon's view on tumours within the brain stem and emanated new perspective in their management. With the growing experience, it has nowadays become evident that the wide variety of tumours here and the very different ways they are treated call for a detailed classification of these tumours. Features such as MR and CT appearance, contrast uptake, exact localisation and also the neurological signs they evoke might be the sound basis for creating subgroups in this special cohort of brain tumour patients. Exophitic tumours growing dorsally into the 4th ventricle24 and intrinsic tumours of the cervicomedullary junction' have a favourable prognosis while the diffusely growing hypodens gliomas (high grade in many cases) or exophitic tumours growing laterally do not exhibit follow up longer than 6–15 months.



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Clinical Neuroscience

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EMIL Pásztor

This paper is a shortened version of an invited lecture given at the Karolinska Institute, Stockholm, on 17th September, 1993, illustrated with 120 slides.

Clinical Neuroscience

Correlation of clinical and molecular genetic findings in malignant brain stem tumors

V. K. Ammon, U. Sure, DN Louis, V. Deimling A.

Brain stem gliomas are rare, predominantly pediatric tumours. Histologically, they are comparable to adult supratentorial astrocytomas. Most of the pediatric brain stem tumours were classified as low-grade astrocytoma (WHO II), anaplastic astrocytoma (WHO III) or glioblastoma multiforme (GBM, WHO IV). Survival of patients with malignant brain stem gliomas as WHO grade III and IV rarely exceeds more than two years. Recently developed molecular genetic techniques gave new insights in tumour biology. Oncogenes and tumour suppressor genes are genetic alterations which can cause tumorous transformation and furthermore malignant progression. Molecular genetic studies of malignant brain stem gliomas have rarely been investigated. Therefore, we set out to study 12 such tumours clinically and 2 by molecular biological methods.

Clinical Neuroscience

Simultaneous occurence of unilateral multiplex meningiomas and syringomyelia

BÜKI András, MÉSZÁROS István, KÖVÉR Ferenc, KASÓ Gábor

Long lasting intracranial hypertension is considered to be a major pathogenic factor of syringomyelia in patients with a Chiari malformation or posterior fossa tumor.

Clinical Neuroscience

Different autoregulatory responses in the cerebellar cortex, neocortex and subcortical gray matter of the rat to systemic hypo- and hypertension


Cerebral autoregulation was investigated in the cerebral and cerebellar cortex, and subcortical gray matter (caudate nucleus) of the rat by means of Laser-Doppler flowmetry. As the vascular architecture of the basal ganglia, the cerebral cortex and the cerebellar cortex have substantial geometrical, onto genetical and pathological differences (3), we tested the working hypothesis that autoregulation of the blood supply to these areas may also be different. Laser-Doppler flowmetry has an ideal time resolution, and it enables analysis of flow-pressure curves (1, 2). The dependency of autoregulation on the rate of change in systemic blood pressure (SABP) in all three regions were confirmed. Control of CBF was significantly different in the subcortical gray matter and the neocortex. Interestingly, no autoregulatory capacity of the cerebellar vasculature was found.

Clinical Neuroscience

Epidermoid tumours of the posterior fossa

K. Bálint, F. Slowik, M. Kordás, J. Juhász, J. Julow

In opposite of the benign biological behaviour of the posterior fossa epidermoids the operation of these tumours a great challenge for the surgeon both theoretical and surgical point of view. We analysed our 14 operated cases clinico pathologically in this retrospective study.

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Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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