Clinical Neuroscience

[Distant neuromuscular effect of locally injected botulinum toxin]

DIÓSZEGHY Péter1, GLAUB Teodóra1, MECHLER Ferenc1

JANUARY 20, 1996

Clinical Neuroscience - 1996;49(01-02)

[Distant neuromuscular effect of locally infiltrated botulinum toxin was studied. The extensor digitorum communis muscle far from the place of injection was sampled with single-fiber EMG in patients treated for spasmodic torticollis. In 2 and 8–16 weeks after the infiltration the mean jitter values increased significantly compared to that of the results before the treatment. Extremely increased jitter values and blocks were found, too. The fiber density was also higher after the botulinum toxin infiltration. The electrophysiological changes may be a consequence of presynaptic blockade, the botulinum toxin induced terminal sprouting of motor axons and formation of new neuromuscular junctions. Parallel with the electrophysiological abnormalities no remote clinical effects were found. The single-fiber EMG proved to be a sensitive method to control the remote neuromuscular effect of botulinum toxin.]

AFFILIATIONS

  1. Debreceni Orvostudományi Egyetem, Ideg- és Elmegyógyászati Klinika

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