Clinical Neuroscience

[Changes in prolactin and cortisol levels after partial epileptic seizures]

KALÓCZKAI Andrea1, HALÁSZ Péter1

JULY 20, 1996

Clinical Neuroscience - 1996;49(07-08)

[Within the framework of presurgical evaluation 14 therapy resistant partial epileptic patients were studied. The prolactin and cortisol serum levels were measured in 15 partial seizures 15, 30 and 60 minutes after the beginning of seizures. Based on the localization of the siezure start on the EEG, ictal, interictal SPECT, MRI and neuropsychological findings the patients were devided into two groups: temporal lobe epilepsy (TLE) and extratemporal epilepsy (ETE). The hormone level measurement was carried out during video-EEG monitoring. In the 11 TLE patients prolactin level increase was found in all cases after the seizures either in the 15th or in the 30th minute samples. In the 4 ETE patients similar increase was found only in 1 patient. Cortisol level increase was found in 10 of the 11 TLE patients and in 2 of the 4 ETE patients. Our findings support the view according which prolactin and cortisol increases occur after seizures involving the temporo-limbic structures. Hormone level peaks are not obligatory consequences of partial epileptic seizures therefore there is no real point in differentiating between epileptic and pseudoepileptic seizures. ]

AFFILIATIONS

  1. Haynal Imre Egészségtudományi Egyetem, Neurológiai Tanszék, Budapest

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