Clinical Neuroscience

A rare entity of acquired idiopathic generalised anhidrosis which has been successfully treated with pulse steroid therapy: Does the histopathology predict the treatment response?

ÖKTEM Özdemir Ece1, ÇANKAYA Şeyda1, UYKUR Burak Abdullah2, ERDEN Simsek Nazan3, YULUG Burak1

SEPTEMBER 30, 2020

Clinical Neuroscience - 2020;73(09-10)

DOI: https://doi.org/10.18071/isz.73.0349

Acquired idiopathic generalised anhidrosis is an uncommon sweating disorder characterized by loss of sweating in the absence of any neurologic, metabolic or sweat gland abnormalities. Although some possible immunological and structural mechanisms have been proposed for this rare entity, the definitive pathophysiology is still un­clear. Despite some successfully treated cases with systemic corticosteroid application, the dose and route of steroid application are controversial. Here, we present a 41-year-old man with lack of genera­lised sweating who has been successfully treated with high dose pulse intravenous prednisolone. We have discussed his clinical and histopathological findings as well as the treatment options in view of the current literature.

AFFILIATIONS

  1. Department of Neurology, Alanya Alaaddin Keykubat University, Alanya, Turkey
  2. Department of Psychiatry, Alanya Alaaddin Keykubat University, Alanya, Turkey
  3. Department of Neurology, Akdeniz University, Antalya, Turkey

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