Lege Artis Medicinae - 1992;2(01 KLSZ)

Lege Artis Medicinae

JUNE 30, 1992

[Antianginal effects of verapamil]

KÉKES Ede

[Verapamil is the prototype of the calcium antagonists. Administration of the drug produces a beneficial antianginal effect due to de creased preload and afterload through vasodilation without marked reflex tachycardia and also due to a special influence on myocardium (negative inotropy and positive lusitropy) in all forms of ischaemic heart disease. Verapamil is also a strong coronary dilator drug. Verapamil was given in doses of 240–360 mg daily. The investigators concluded that exercise... tovább »

Lege Artis Medicinae

JUNE 30, 1992

[Verapamil treatment in hypertrophic cardiomyopathy]

DÉKÁNY Miklós

[The main aims of therapy in hypertrophic cardiomyopathy, in which ways the symptoms of the patients can be decreased and their survival can be made longer, are as follows: to ameliorate the impaired ventricular relaxation during diastole, to decrease or abolish the obstruction to the left ventricular outflow in systole, as well as to prevent or abolish the atrial and ventricular arrhythmias. Verapamil treatment can be advantageous in each of the above respect. The author describes the... tovább »

Lege Artis Medicinae

JUNE 30, 1992

[Application intravenous verapamil in hypertonic crises]

NAGY Viktor, ISKUM Miklós

[Hypertensive crisis becomes manifest in two clinically well distinguishable forms. Life threatening cases require immediate intervention, while in cases not immediately life threatening, the situation is less critical, but a delay in treatment may lead to serious organ damage. The authors administered 5 mg verapamil intravenously during 3 minutes to 46 patients (mean age 65,7 years, 31 women, and 15 men). The initial blood pressure of 226/125 mmHg decreased to 193/97 mmHg, and the heart rate... tovább »

Lege Artis Medicinae

JUNE 30, 1992

[Verapamil treatment in hypertension]

FARSANG Csaba

[The author describes the mechanisms of action of verapamil, the first calcium antagonist, and also shortly summarizes its indications and ways of administration in hypertension. Its role in antihypertensive combinations and interactions are also conscisely dealt with.]

Lege Artis Medicinae

JUNE 30, 1992

[The calcium channel blocker verapamil basic properties, pharmacokinetics, interactions, side effects]

KÉKES Ede, FARSANG Csaba

[The family of calcium channel blockers is very large and includes its prototype, the monophenylalkylamin drug, verapamil. It is a non-selective vasodilator which exerts a powerful effect equally on myocardium, conducting and nodal tissue of the heart, and both central and peripheral vasculature. Verapamil is almost completely absorbed after oral administration. However, because of extensive first-pass hepatic metabolism, only about 20% of the drug is bioavailable. The elimination phase is slow... tovább »

Lege Artis Medicinae

JUNE 30, 1992

[Effects of verapamil on cardiac arrhythmias]

ZÁMOLYI Károly

[Verapamil, a „first generation" calcium anta gonist and synthetic papaverine derivate, was initially introduced as a potent peripheral and coronary vasodilator. It was later found to have significant antiarrhythmic activity, the mechanism of which was related to selective inhibition of transmembrane fluxes of the calcium. The electrical activity of the sinus node and of the atrioventricular (AV) node depends primarily on slow inward Ca2+ currents, therefore it is logical to expect that calcium... tovább »