Specialities

Gastroenterology

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Paradigm shift in the drug therapy of HFrEF]

HEPP Tamás, VARJAS Norbert, BENCZÚR Béla

[The incidence and prevalence of heart failure (HF) is constantly increasing, its mor­bidity and mortality are still high, thus the disease burden is huge and its proper treatment is of paramount importance. Subs­tantial evidence on improving its prognosis remains available only by the treatment of chronic heart failure with reduced left ventricular function (HFrEF). There have been published a number of “milestone” studies in the last decades, the results of which fundamentally determined the... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Coronavirus disease-2019 among rheumatic musculoskeletal patients – possible outcomes of infection, severe disease development and effectiveness of vaccination]

HODINKA László

[The prevalence of coronavirus infection of patients with inflammatory and rheumatic diseases does not differ significantly from the rate of the disease in the local general population. Patients treated with higher doses of corticosteroids, especially those with more severe systemic autoimmune disease, contract coronavirus infection at a higher rate. The risks of hospitalisation and the mortality rate do not differ significantly from those of the general COVID infected population. Patients... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[Bradykinin-cytokin-storm and its pathomechanism in very severe Covid-19]

SZÉKÁCS Béla, VÁRBÍRÓ Szabolcs, KÉKES Ede, DEBRECZENI Lóránd

[The authors review the pathomechanism of severe COVID-19 leading to systemic uncontrollable inflammation, thrombotic events and other complications. The review includes the extremely complex interactions between the infecting coronavirus and the in loco cellular-tissue contact system, the kinin-kallikrein and the renin-angiotensin systems. Authors critically evaluate some potential therapeutic interventions aiming at the mitigation of the dominant bradykinin-cytokine storm in the background of... tovább »

Lege Artis Medicinae

SEPTEMBER 16, 2021

[RAAS inhibitors therapy – COVID-19 pandemic]

KÉKES Ede

[Acute respiratory syndrome with various signs and outcomes caused by the SARS-CoV-2 virus is the biggest challenge facing health systems worldwide today. The renin-angiotensin-aldosterone and kinin-kallikrein systems and within these two endopeptidases (ACE and ACE2) play a crucial role in the developing clinical feature of COVID-19. Adverse effects of the ACE-stimulated Ang II/AT1R axis (oxidant, pro-inflammatory effect, vasoconstriction) are counterbalanced by the ACE2-induced AT2R and MasR... tovább »

Hypertension and nephrology

SEPTEMBER 13, 2021

[Membranous glomerulopathy: two cases]

BÓDI Brigitta, FEJES Réka, KARDOS Magdolna, DEÁK György

[Summary – Membranous glomerulopathy (MGP) is the most frequent cause of nephrotic syndrome in adults. It is classified as a primary autoimmune disease or secondary MGP due to malignancies, autoimmune diseases, infections or adverse drug reactions. Here we present two cases of MGP.]

Hypertension and nephrology

SEPTEMBER 13, 2021

[The treatment of patients with hypertension and HFpEF. The role of MRA (mineralocorticoid receptor antagonist), ARNI (angiotensin receptor blocker – neprilysin inhibitor), and the SGLT-2 inhibitors ( sodium-glucose-cotransporter-2 inhibitors)]

MASSZI Gabriella

[The prevalence of the symptomatic form of heart failure with preserved ejection fraction (HFpEF) often causes therapeutic problem for physicians. Hypertension is one of the most frequent concomitant illness among many comorbidities. Therefore its treatment, care and monitoring needs special attention, as well. Newer therapeutic options will be reviewed in the light of the results of the studies concerning treatment of HFpEF and high blood pressure.]