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Clinical Neuroscience

MAY 30, 2012

[European treatment recommendation of neuromyelitis optica spectrum disorders: critical remarks and case discussion]

KÕSZEGI Edit, ILLÉS Zsolt

[Neuromyelitis optica is a demyelinating disease of the central nervous system mediated by antibodies against the waterchannel aquaporin4 (AQP4). In a number of cases the clinical manifestation is spatially limited. Such events of separate longitudinally extensive transverse myelitis (LETM) or relapsing/bilateral optic neuritis (RION/BON) are defined as NMO spectrum diseases. The diagnosis is further challenged by anti-AQP4 seronegative cases. While chronic immunosuppressive therapy should be introduced in definitive NMO, treatment strategy of the NMO spectrum is less defined. Recent EFNS guidelines recommend chronic immunosuppressive treatment of NMO spectrum diseases depending on the clinical course even in AQP4-seropositive cases. Presenting a case with relapsing optic neuritis, here we emphasize the importance of early immunosuppressive therapy in all seropositive NMO spectrum diseases regardless of relapse severity, in order to prevent an upcoming devastating relapse, i.e. NMO conversion.]

Lege Artis Medicinae

MAY 21, 2006

[DISEASES OF THE SPINE ACCOMPANIED BY LOWER BACK PAIN]

TÓTH Edit Ágnes

[It is estimated that 80% of the adult population consult their general practitioner for lower back pain at some point in their life. Apart from family doctors all medical specialists may encounter this complaint, which makes the wide-spread knowledge of this topic desirable. Pain associated with spinal diseases has two distinct types, non-inflammatory and inflammatory pain. Non-inflammatory diseases may cause moderate pain that increases with movement or functional limitation lasting for a few days, other times cause a pain pattern of varying intensity that radiates to the lower extremities and is accompanied by neurological symptoms, more rarely, present as cauda equina syndrome. In most cases, the underlying cause of the symptoms is a degenerative disorder of the spine. Spinal pain of inflammatory origin, on the other hand, is characterized by pain that worsens at night, characteristically narrowed mobility, changes in the skin, mucous membranes and joints, and sometimes fever or bad general condition. This type of pain is primarily caused by seronegative spondyloarthritis or, rarely, various pyogenic or non-pyogenic bacterial infections. Management of lower back pain aims to cease pain and restore function. These are achieved by unloading, medical pain relief, antiinflammatory drugs, muscle relaxants and antidepressants, as well as physiotherapy. In special cases the administration of other drugs (e.g., antibiotics) may be necessary along with pain relief. In seronegative spondyloarthritis traditional approaches will hopefully be supplemented by biological therapy in the future. This review of recently published results on spinal diseases accompanied by lower back pain will possibly help doctors in state-of-the art care of their patients.]

Lege Artis Medicinae

FEBRUARY 21, 2004

[EYE DISORDERS ASSOCIATED WITH MUSCULOSKELETAL DISEASES]

VOGT Ferenc

[The diseases of connective tissue and musculoskeletal system frequently associated with typical eye disorders. These can either be mild, recovering fully after treatment or more serious with persisting symptoms and destructive changes resulting in permanent loss of sight Eye symptoms can occur in the following diseases: rheumatoid arthritis, juvenile chronic arthritis, neonatal onset multisystem disease, ankylosing spondylitis, seronegative spondarthrities, Reiter’s syndrome, Behçet’s syndrome, Lyme disease, systemic lupus erythematosus, scleroderma, polyarteritis nodosa, Wegener’s granulomatosis, giant cell arteritis, erythema nodosum, relapsing polychondritis, sarcoidosis, Marfan’s syndrome, osteogenesis imperfecta.]