Search results

Clinical Neuroscience

JULY 30, 2017

[Guidelines for the treatment of traumatic brain injury - 2017]

BÜKI András, BARZÓ Pál, DEMETER Béla, KANIZSAI Péter, EZER Erzsébet, TÓTH Péter, HORVÁTH Péter, VARGA Csaba

[Traumatic brain injury (TBI) is recognized to be the main cause of death and disability in the first four decades representing a major socio-economical problem worldwide. Recent communications revealed a particularly worrying image about the quality of care for TBI in Hungary. For any improvement a systematic approach characterized by utilization of scientific evidence based guidelines forming the basis for close monitoring of the actual care are considered a prerequisite. In Hungary the first evidence based guidelines in the field of TBI have been issued by the National Society for Anesthesiology and Intensive Care more than two decades ago followed by joint guidelines of the Hungarian Neurosurgical Society and the Hungarian College of Neurosurgeons. These publications were primarily based on the work of the European Brain Injury Consortium as well as guidelines issued by the Brain Trauma Foundation. Recent renewal of the latter and a need to refresh the outdated national guidelines was met by a call from regulatory authorities to issue the updated version of the Hungarian TBI-guidelines. The present review is aimed to briefly summarize the most fundamental elements of the national head injury guidelines that would hopefully be officially issued in a far more detailed format soon.]

Clinical Oncology

MAY 20, 2016

[Non-surgical treatment of the biliary tract and gallbladder cancer]

PIKÓ Béla, LACZÓ Ibolya

[Biliary tract cancers are rare, hence only a few high level of evidences related to their treatment are available. The successful treatment and the only chance for long-term survival are based on the radical surgical resection. After the fl uoropyrimidin based protocols chemotherapy regimens prefer gemcitabine combinations (cisplatin, oxaliplatin, capecitabine) or FOLFIRINOX, considering the patient performance status as well. There are no registered targeted therapy in this indication, the most experiences were acquired with erlotinib; nowadays the optimal treatment can be selected by the molecular genetic profi le of the tumour and not by the results of the clinical studies. The radiotherapy and the radiochemotherapy can be administered preoperatively, postoperatively and for palliation as well, in addition to the conventional percutaneous radiotherapy, brachytherapy, intensity-modulated radiotherapy, intraoperative irradiation, radioembolization can also be administered depending on the technical equipments. Besides the photodynamic therapy and several ablation therapies, even interventional radiological procedures can play a signifi cant role.]

Journal of Nursing Theory and Practice

AUGUST 30, 2016

[The evolution of skull reconstruction surgical techniques and it’s impact on patient’s care and the effect on patients from the nursing perspective]


[Background: Facts support that decompressive craniectomy allaviates life-threatening acute high intracranial pressure and it is performed worldwide. Less attention has been paid to the late negative consequences of the widely open cranium. Hence there is a need for timely closure of the defect and precise cranioplasty. Objective: The goal of the present study was to compare the clinical results and patient care data gained by a novel cranioplasty method, the so called computer-aided design and computer-aided manufacturing (CAD/CAM) technique, versus conventional operative procedures. Patients and Methods: Seventy patients were operated on by conventional reconstructive methods (n=70) in our department between 2004 and 2006. These patients served as the control group. Sixty patients had got cranioplasty with individually prepared cranial implants using the CAD/CAM technique (n=60) in 2011 to 2013. The total number of the investigated patient population was n=130. Age distribution of the group varied from 17 to 80. Retrospective neurological and patient care data were collected and compared at the two surgical technique. Results: More precise coverage of the cranial defect and acceptable cosmetic result were achieved in every case operated on with the CAD/CAM surgical technique. The ratio of patients with persistent vegetative-state decreased, and the neurological outcome improved following surgery using the CAD/CAM method. The patient care was easier and rehabilitation procedure was more favourable at the CAD/CAM population. Iatrogenic infection and wound- healing complications were less frequent at the department between 2011 and 2013. The quality of patient care have been improving considerably by regular education and continuous development of nursing standard. Patients need for hospital stay decreased, therefore health economic aspects and cost-benefit ratio improved at the Department of Neurosurgery in the Péterfy Hospital. Conclusion: This study demonstrates an improvement in neurological outcome and easier patient care following CAD/CAM reconstructive surgery of cranial defects in status of normalized intracranial pressure. Results support the extended use of the method in the XXI. Century. ]

Clinical Oncology

SEPTEMBER 05, 2015

[Up-to-date treatment of head and neck cancers]


[The head and neck squamous cell cancer is often detected at an advanced stage, resulting in dismal prognosis despite the relevant developments of the oncotherapy in the last decades. The introduction of new techniques, new drugs and combinations though improves the survival for certain subgroups of patients, meanwhile the organ-function preservation and side effects reduction approaches lead to improved quality of life. The preventive-supportive care prior and during the therapy (dental care, nutrition, toxicity management) and the complex rehabilitation has paramount importance. MRI and 18FDG PET-CT and the advanced methods of molecular pathology became part of the diagnostic work up. The selection of the therapy based on the tumor characteristics, HPV detection, on the patient’s condition and wishes, as well as on multi-disciplinary team decision based on the available technical options. Early stage tumors can be successfully treated either by surgery alone or by radiation therapy. For locally advanced cases concomittant chemo-radiotherapy stays in the axis of the complex management using advanced radiation technique (IGRT-adaptive- IMRT) with cisplatin (or if contraindicated with cetuximab), which could be complemented by induction chemotherapy and/or surgery. Several new approaches are currently being tested in clinical studies after establishment of cisplatine-cetuximab treatment for recurrent/metastatic tumors. In the future, detection of molecular processes and driver mutations could result in development of more effective targeted anti-tumor agents, and individual molecular tumor profi le guided therapy, including the various forms and combinations with emerging immunotherapy.]

Clinical Neuroscience

MAY 30, 2016

[Closure of nasocranial fistulas with “bath-plug” technique and multilayer reconstruction]

PISKI Zalán, BÜKI András, NEPP Nelli, BURIÁN András, RÉVÉSZ Péter, GERLINGER Imre

[Background and purpose - In case of dehiscenses developing on the anterior scull base, complete closure resulting in the cessation of the communication between the nasal cavity and the intracranial space is mandatory as soon as possible, in order to prevent serious complications. With the development of the endoscopic techniques, the endonasal management for the reconstruction has become available in recent decades. Methods - We aim to present the reconstruction techniques applied in our department in the cases of two patients recently operated at our institute. The choice of methods primarily depends on the size and the localization of the defect. Dehiscenses under 5 mm of diameter can be closed with the so called “bath-plug” technique, while bigger defects, where the required closure of the plug is not possible, can be solved with multilayer reconstruction. We use autogenous fascia, fat and muco-periosteum in both cases. Results - Our patient, who underwent the aforementioned “bath-plug” procedure, could be discharged after a few days of uneventful postoperative period. During a tenmonth follow- up period new fistula formation was not observed. In the case of a patient who underwent multilayer reconstruction, meningitis occurred postoperatively, which was resolved after antibiotic therapy. During a 17- month follow- up period recurrent liquorrhoea did not occur. Conclusion - With suitable technical background and appropriate endoscopic skills the surgeries of the anterior skull base cerebrospinal fluid fistulas can be performed efficiently and with low complication rate. These are minimally invasive procedures accompanied by less surgical trauma, morbidity and shorter hospitalization, hence these techniques are considered to be cost-effective and well- tolerated for the patients.]

Clinical Oncology

MAY 10, 2015

[Invasive endoscopy in oncology]


[Recent advances in interventional gastrointestinal endoscopy have led to a large variety of new diagnostic and minimally invasive endoscopic surgical procedures in oncological patients. Endoscopic ultrasound with the possibility of fi ne needle aspiration is currently one of the most accurate imaging technology for adequate staging of gastrointestinal cancers including oesophageal, gastric, rectal and pancreatic cancer. Endoscopic mucosal resection and endoscopic submucosal dissection offers a minimal invasive endoscopic treatment modality as an alternative for laparoscopic surgery for patients with early intramucosal neoplasias, fl at adenomas and laterally spreading tumors of the oesophagus, stomach, duodenum and colorectum. Self-expandable metal stents are now readily available for endoscopic palliation of different type of malignant gastrointestinal obstructions including oesophageal, duodenal, colonic and biliary stenosis. These recent developments of interventional gastrointestinal endoscopy lead to more precise and accurate tumor staging and more effective oncological therapy for patients with gastrointestinal cancers.]

Clinical Neuroscience

MARCH 30, 2016

Hungarian experiences with the Beliefs About Attractiveness Scale


Background and purpose - Sociocultural influences regarding bodily appearance and their psychological consequences play a considerable role in the development and maintenance of body image disturbance and eating disorders. The purpose of the study was to explore the psychometric properties of the Beliefs About Attractiveness Scale-Revised and its correlates among young adults in Hungary. Methods - In our cross-sectional online study, participants were 18-35 years old (N=820, 40% male). Measures: self-reported anthropometric data, Beliefs About Attractiveness Scale-Revised, Eating Disorder Inventory, SCOFF questionnaire, Sociocultural Attitudes Towards Appearance Questionnaire-3, and Rosenberg Self-esteem Scale. Results - The exploratory factor analysis showed that the fit indices of the three-factor solution are acceptable (c2(171)=5124.8, p<0.001, CFI=0.944, TLI=0.918, RMSEA=0.054, SRMR=0.030). Along the original ‘Importance of being thin’ and the ‘Importance of being fit’ factors, a third factor emerged, namely the ’Life fulfilment aspect of attractiveness’ factor. Internal consistency and construct validity of the scales were confirmed. Among those who were at risk of developing an eating disorder, all of the measured beliefs were significantly greater than among those who were not at risk (thin: Z=6.501, p<0.001, Cohen’s d=0.63, fit: t(818)=-4.749, p<0.001, Cohen’s d=0.41, and life fulfilment: t(239)=-5.702, p<0.001, Cohen’s d=0.53). Conclusion - The Hungarian version of the Beliefs About Attractiveness Scale-Revised is a reliable, valid measure and we suggest its introduction into Hungarian research. Relationships between beliefs about attractiveness and self-esteem, body image and eating disorders suggest intervention opportunities in with regards to prevention and treatment of eating disorders.

Journal of Nursing Theory and Practice

AUGUST 30, 2015

[Investigation of the factors infl uencing among members of the care team in terms of the identity of the leadership]


[Aim of the research: The objective of the research is to map the different subcultures, examine in detail the role of subgroups and the influencing factors that are determining the relationships between the members of the Institution’s healthcare provider teams. Research and sampling methods: Data and information collection was advisedly planned, guided and implemented with help of personal communication techniques. With regard to the final form of data collection method based on standardized preliminary research plan, I’ve selected partly structured and unstructured interview forms, with closed and open questions. The analysis was performed by interviewing 10 chief physicians and 10 head assistants. Results: 100% of the interviewed leaders related that competencies are determined primarily by skills, human attitudes and personality. The analyzed subjects confirmed that well defined expectations expressed by leaders and open communication is enhancing the close co-operation between team members and is reducing hereby the work stress. The investigation underpinned that good co-operation of team leader couples, or lack of co-operation has strong impact on the team’s performance and on the relationships between team members. Conclusions: Identifying, understanding and handling our own or other people feelings, the behavior with our fellow creatures is matter of emotional intelligence, and not of cognitive capability. With help of deep interviews, valid facts, leadership manners, management of conflict situations were identified and pointed at the influencing factors of department’s micro culture and the work atmosphere of the organization. Diversity of the work, rate of workplace monitoring, rate of qualifications and skills required for the job, quality of interpersonal relationships are contributing to workplace satisfaction and the evolution of team spirit among colleague ]

Journal of Nursing Theory and Practice

JUNE 30, 2015

[History of operating room nursing profession]


[Complete personal and material condition are foundations of operation. Surgical assistant (scrub nurse) is indispensable part of surgical group of workers who has significant role in direct operation beside preparation and after operation periods. Qualified scrub nurse instrumentation to surgeon who operates and to his assistant which required perfect knowledge of every means and materials. Technical development result in change of surgery’s repertoire: new tipes of procedures and devices. Surgical assistants have to be abreast with developments, with changing working environment, qualification and laws. Author represent the history of surgical assistant work from the begining to nowadays. Author demonstrate advent of surgical assistant profession, change of vocational training and attached laws, exercises of scrub nurse at the present time and in the past. ]

Lege Artis Medicinae

SEPTEMBER 20, 2015

[Perioperative management of patients taking new oral anticoagulants - dabigatran in focus]

MÁRK László

[Appearance of new oral anticoagulants (NOAC) on the market requires a basically new approach from the doctors compared to vitamin K antagonists (VKA), the only oral anticoagulants used for several decades. These new drugs are at least as effective in the prevention of thrombotic events as the old ones and have the advantage that no regular laboratory monitoring is needed. Compared to the VKA a different management is required also in the perioperative care of patients taking NOAC. There is no need for bridge therapy, i.e. low-molecular-weight heparin (LMWH). The smaller surgical procedures can be performed 24 hours after the last dose of NOAC if it is administered once a day or 12 hours in case of agents administered twice a day. When a large surgical procedure is planned the drug should be stopped 24-96 hours before. The therapy should be resumed 6-8 hours after the procedure in low, 48-72 hours later in high bleeding risk cases. In a Canadian prospective study a protocol was used in which the stopping and resumption of dabigatran was recommended based on the bleeding risk and its half-life depending on the renal function. In 541 surgeries (60% with standard, 40% with increased bleeding risk) the occurrence of serious bleeding events was 1.8%, that of minor bleedings 5.2%. During the study one thrombotic event (TIA) occurred (0.2%). At the end of the article the author also makes a recommendation for stopping and resuming dabigatran therapy in case of tooth extraction, endoscopic biopsy and cholecystectomy.]