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Hypertension and nephrology

APRIL 20, 2015

[Fructose-induced hyperuricaemia]

NAGY Judit, KISS István, WITTMANN István, KOVÁCS Tibor

[The consumption of fructose and fructose-based sweeteners has dramatically increased in the last hundred years and correlates epidemiologically with the rising prevalence of obesity, hypertension and metabolic syndrome worldwide. The administration of fructose to animals and humans increases uric acid generation independently from excessive caloric intake. Fructose ingestion may also be a risk factor of chronic kidney disease, that includes glomerular hypertension, vascular alterations (arteriolosclerosis) and albuminuria. The discovery that fructose-mediated generation of uric acid may have a casual role in metabolic syndrome and kidney disease provides new insight into pathogenesis and therapies for these important diseases.]