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Lege Artis Medicinae

DECEMBER 21, 2011

[Oxytocin as a neurotransmitter: beyond the peripheral scope]

VARGA Katalin

[Besides its effect on the uterus and breasts, oxytocin also regulates affiliative behaviour. The so-called central oxytocin effect influences pair bonding, maternal care and attachment through the regulatory functions of oxytocin that acts as a neurotransmitter within the brain. The central oxytocin effect increases trust and social support, decreases fear and anxiety, and promotes wound healing. These effects form the basis of the stress-triggered, oxytocin-based ‘calm and connection’ reaction. Some methods that are widely used in modern obstretric practice - such as the use of synthetic oxytocin for inducing or speeding up labour or epidural anaesthesia - hinder the psycho-emotive effects that are based on natural oxytocin. Epigenetic studies performed in animals indicate that the oxytocin effect experienced at birth can be transgenerational.]

Lege Artis Medicinae

MAY 20, 2011

[Specialists’ mobility in surgery and gynaecology-obstetrics in Hungary]


[The new government inaugurated in 2006, started a most comprehensive professional and territorial restructuring of the hospital network in the recent decades. While performing it, the health administration took in account also the considerable re-allocation of the domestic medical workforce. The joint mobility program launched by the Ministry of Health and the Ministry of Social Affairs and Labour supported doctors and nurses changing their habitation provided they had lost their working place by reorganisations. The obvious failure of this program indicated very clearly the lack of mobility of involved physicians (only 24 physicians and 11 nurses applied to be supported). The present study based on data of registered specialists in December 2009 analyses the graduate training and professional mobility patterns of surgeons and gynaecologist-obstetricians born in Hungary and abroad as well. Among surgeons (N=1469) there is 13.5% and among gynaecologist-obstetricians (N=1377) 10.6% the proportion of those born abroad. Results obtained show a very strong adherence of domestic professionals to the regional community, however this adherence exists parallel with the crossnational migration of the same workforce both indicating the essential role of immigrant specialists while providing health care in this country.]

Lege Artis Medicinae

JUNE 20, 2011

[Committed physicians, emotional resonance for a better physician-patient relationship]

LAZÁNYI Kornélia, SZLUHA Kornélia

[With the advent of holistic medicine in the second half of the 20th century, the range of behavioural patterns that are expected from healthcare workers has also changed. Nowadays, numerous references in literature put emphasis on the potential positive impact of personal interactions between physician and patient on the healing process and overall well-being of patients. However, it does not come naturally to all workers with caring professions to seek personal interactions with their patients or display appropriate emotions. Some will have to make deliberate efforts, perform emotional labour, to achieve that goal. A healthcare worker’s commitment to healing and caring may make it easier for him/her to perform emotional labour. Emotional labour and commitment of 84 healthcare workers involved in oncology, and organizational factors with impact thereupon, were studied to explore the potential relationship between commitment and emotional labour. PANAS-X questionnaires were used to quantify emotional labour, while commitment and influencing factors were surveyed by means of explicative questions. Our findings confirmed a correlation between commitment and genuine acting as corroborated by literaure data. It was demonstrated that committed healthcare workers’ spontaneous emotions were more in compliance with what their patients expected them to display, and even their behavioural patterns were more in tune with the patients’ expectations. Confirmation as an organizational factor and colleague/ patient attitudes were found to have the strongest impact on commitment. It is essential that selection criteria for healthcare workers include examination for an altruistic caring attitude. Even more importantly, operators and managers of healthcare institutes should make efforts to create a good working environment and offer regular confirmative feedbacks for improved commitment by their employees.]

Lege Artis Medicinae

MAY 20, 2004



[The DNA-based assays have the potential to be a powerful diagnostic tool given its ability to specifically identify H. pylori DNA. Markers used include general H. pylori structures and pathogenetic factors like ureaseA, cagA, vacA, iceA. DNA or bacterial RNA for polymerase chain reaction (PCR) assays can be collected from gastric biopsy, gastric juice, stool, buccal specimens. PCR can yield quantitative and genotyping results with sensitivity and specificity that approaches 100%. A clear trend in the direction of the determination of quantitative H. pylori infection by real-time PCR can be observed. Fluorescent in situ hybridisation (FISH) and restriction fragment length polymorphism (RFLP) are suggested for routine antibiotic resistance determination. To identify the DNA structure of organism and its virulence factors may be feasible by using oligonucleotide microarray specifically recognising and discriminating bacterial DNA and various virulence factors. DNA based H. pylori diagnosis yields higher sensitivity, however, specificity requires sophisticated labour environment and associated with higher costs.]

Clinical Neuroscience

FEBRUARY 20, 2003

[The role of reconstructive surgery for upper limbs in the rehabilitation of tetraplegia (case report)]


[As part of the rehabilitation of tetraplegical patients, movement improving operations have been carried out for more than 30 years. The scant results of the early 70's caused such a standstill and division among professionals, that operations on the upper limbs on tetraplegical patients became questionable. The authors started operating upper limb reconstructions on tetraplegia patients for achieving a basic hand function i.e. keypinch, grasping etc. in 2001. Three cases are quoted and one of them, operated ten months ago is described in details. The postoperative treatment of the other two patients has not finished yet. In 1998, a twenty-three years old girl had her fifth and sixth cervical vertebra broken in a car accident. The rugged break of the fifth vertebral body damaged the spinal chord. After the accident all four limbs became ataxic and a complete numbness occurred distally from the thoracic level of the chest. The patient went through a CV corpectomia, a corpus complementation, a CIV-V dissectomia and a CIV-VII ventrofixation. After the operation the movements of the upper limbs improved but those of the lower limbs did not. Her general condition stabilised after the treatments at the intensive care and the laryngological, the urological and the plastical surgery as well as the complex therapy at the rehabilitation department. She moved around in a wheelchair. After a para-coordinational treatment she was able to lift up small objects, but because of her paralysed bending and stretching finger muscles she was not able to hold heavier objects with her hands. In March 2002 a grip improving operation was carried on her dominant right hand. Twelve weeks after the operation she could lift up a weight of 2 kg and she was able to keypinch and grip with force.]