Lege Artis Medicinae

[The role of langerhans' cells in the development of cervical cancer]

PETE Imre1, SÁPI Sándor2, GONDA Gábor3

AUGUST 31, 1994

Lege Artis Medicinae - 1994;4(08)

[While the number of deaths from cervical cancer of women over the age of 45, has fallen in the recent years the mortality in women under the age of 35 has increased. The reason for this change is not clear. A large number of analytical studies tried to identify the risk factors for cervical cancer (age, marital status, time of first intercourse, number of sexual partners, coital frequencies, circumcision of partners, menstrual patterns, gravidity, type of contraception, smoking, viral infection, socioeconomic circumstances) but the real con nection between the disease and the varions risk factors remained unclear. The results of these studies suggest that, the 'one hit one tumor' hypothesis can't be proven, and it seems more appropriate to cousider a complex effect of these etiologic factors acting on the altered immunologic status of the cervix uteri. We tried to concentrate on one out of these factors from the literature which may play a cardinal role in the development of CIN or invasive cervix cancer. It is evident from the literature that the macrophages present in the cervix tissue in CIN, or infiltrating the tumor tissue in invasive cancer, could influence either the development of cervical cancer or the prognosis of the disease. It has long been known that in the cervical tissue there are a specific type of dentric cells taking part in the antigen presentation process. The examination of behavior, distribution and activity of these so – called Langerhans cells due to the exogen effect in the cervical tissue may be a which contributes to the understanding of the process leading to the development of CIN. ]

AFFILIATIONS

  1. Országos Onkológiai Intézet Nőgyógyászati Onkológiai Osztály Budapest
  2. Fővárosi Önkormányzat Szt. János Kórház Patológiai Osztály Budapest
  3. Országos Onkológiai Intézet Humán és Kísérletes Daganatpatológiai Osztály Budapest

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