Lege Artis Medicinae

[The effect of (-) deprenyl monotherapy on parkinson's disease]

MÁLLY Judit1

DECEMBER 25, 1991

Lege Artis Medicinae - 1991;1(18)

[50 de novo patients with Parkinson's disease were investigated in a retrospective study after deprenyl monotherapy and a combination of deprenyl and levodopa. The study involved subjects with different Hoehn-Yahr stages. During the treatment period the distribution of age (below or above 60 years) among the Hoehn-Yahr stages was similar to that of the baseline period, while the clinical disability for the patients starting with hypokinesis meant a more severe state compared to the cases with tremor. During the administration of deprenyl, the progression of males was slower than that of females. (-) Deprenyl was effective in decreasing hypokinesis, while rigidity improved less. The reduction of parkinson symptoms developed slowly and was independent of the severity of Parkinson's disease. The maintenance of deprenyl monotherapy showed a high individual variation but the average period was about one year. The termination of the effect of deprenyl was rapid, however, not progressive. The time of the appearance of the side effects of additional levodopa was not delayed by the deprenyl treatment. The reduction of parkinson symptoms by deprenyl and its prolongation of the introduction of levodopa therapy might involve other neurotransmitters than endogenous dopamine.]

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  1. Szent György Kórház Ideggyógyászati Osztály Székesfehérvár

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