Lege Artis Medicinae

[Role of platelet function in the pathogenesis of alzheimer's disease]

HASITZ Mária1, LIPCSEY Attila1, RÁCZ Zoltán2

SEPTEMBER 30, 1992

Lege Artis Medicinae - 1992;2(09)

[Dementias, especially those of Alzheimer type represent very serious types of disease in the elderly. Amounting evidence suggests that Alzheimer's disease is reflected in the platelets of the patients. Our results and the data of scientific literature have been summarized. In vitro parameters of platelet shape and aggregation were compared. Platelet shape, characterized by aggregometer oscillation amplitude, and the initial rate of 50 uM ADP-induced aggregation have been recommended for supporting the diagnosis of Alzheimer's disease or Alzheimer-type senile dementia. Our results and those of others revealed that the function of the Alzheimer platelet is influenced by two effects: the plasma medium and the genetic background resulting in the change of the platelets. The results suggest that both effects are involved in the vitro functions detected.]

AFFILIATIONS

  1. Szent János Kórház Neuropszichiátriai Osztály Budapest
  2. Országos Haematológiai Intézet Neuropszichiátriai Osztály Budapest

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