Lege Artis Medicinae

[RARE UTERINE MALIGNANCY: THE ENDOMETRIAL ADENOSARCOMA]

TARJÁN Miklós, SÁPI Zoltán, BENTZIK András, CSERNI Gábor

SEPTEMBER 18, 2004

Lege Artis Medicinae - 2004;14(08-09)

[INTRODUCTION - Müllerian adenosarcoma is typically composed of benign glandular epithelial elements admixed with malignant sarcomatous stroma. This rare tumour usually originates in the endometrium and grows as a polypoid mass into the endometrial cavity. CASE REPORT - We report the case of a woman aged 32, who presented with abnormal vaginal bleeding and was diagnosed with an adenosarcoma after a curettage and subsequent hysterectomy. CONCLUSION - This tumour has a relatively good prognosis among the mixed mesenchymal sarcomas of the uterus and the majority of patients with this neoplasm survive. The gynecologists and pathologists should be aware of this entity and discuss the risks and benefits of radiation and chemotherapy, which is usually indicated for malignant diseases.]

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Lege Artis Medicinae

[Abdominal compartment syndrome: the cause of postinjury multiple organ failure. Summary of the article]

BALOGH Zsolt, MCKINLEY BA, COX CS Jr, ALLENS SJ, COCANOUR CS, KOZAR RA, MOORE EE, MILLER CC, WEISBRODT NW, MOORE FA

Lege Artis Medicinae

[FIXED-COMBINATION THERAPY IN ANTIHYPERTENSIVE TREATMENT]

BARNA István

[Target blood pressure and reduction in cardiovascular morbidity and mortality have to be accomplished always with the consideration of target organ lesion. Fixed-combination antihypertensive therapy has become accepted based on the recommendations of international and Hungarian medical associations that are aware of the results of evidence based medicine. The fix combinational treatment is more favorable for patients’ compliance. The daily dosage of drugs with 24 hour effect improves the patients’ cooperativeness. During fix combinational treatment higher efficiency, smaller dose and fewer side effects were observed. In combination, the effects of the drugs on blood pressure are additive without any increase in adverse effects. Last, but not least the cost of drugs of fixed combination are lower than buying the drugs separately. After careful consideration the fixed combination therapy can be recommended to the everyday practice.]

Lege Artis Medicinae

[The diagnosis and therapy of chronic obstructive pulmonary disease - Recommendation of the 2003 consensus conference]

BÖSZÖRMÉNYI Nagy György

Lege Artis Medicinae

[RISKS AND BENEFITS OF MEDICATION IN PREGNANT WOMEN]

CZEIZEL Endre

[The Hungarian Case-Control Surveillance System of Congenital Abnormalities can provide appropriate data for the evaluation of risk and benefits of drugs and pregnancy supplements in pregnant women. Among the main principles, the importance of time factor (the first trimester concept is outdated) and the explanation of frequent false teratogenic findings (e.g. recall bias, chance effect, etc.) are discussed. The main conclusion is that at present the exaggerated teratogenic risk of drugs is much more harmful for the fetus than the rare teratogenic effect of some drugs themselves. Medical doctors and other experts therefore need more education to know the principles and findings of modern human teratology because it may help us to have a better balance between the risks and benefits of drug use during pregnancy. On the other hand, the primary prevention of neural-tube defects and some other congenital abnormalities is demonstrated by periconceptional folic acid or folic acid-containing multivitamin supplementation. Unfortunately, this new method is used rarely and inappropriately (due to the late onset of supplementation) in Hungary.]

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