Lege Artis Medicinae

[HOPE: Heart Outcomes Prevention Evaluation]

YUSUF S, SLEIGHT P, POGUE J, BOSCH J, DAVIES R, DAGENAIS G.

MARCH 10, 2010

Lege Artis Medicinae - 2010;20(01 klsz)

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Lege Artis Medicinae

[Cardiovascular prevention]

ZÁMOLYI Károly

[Cardiovascular diseases are the leading causes of morbidity and mortality worldwide. Before the appearance of overt symptoms of various diseases, a silent, progressive condition exists. The main goal of prevention guidelines is to reduce the incidence of first and recurrent clinical events, which include coronary heart disease, ischaemic stroke and peripheral artery disease. Modification of risk factors has been proved to reduce cardiovascular mortality and morbidity, especially in patients with a high risk. By reducing the risk of substantial cardiovascular events it is possible to ameliorate premature disability, prolong survival and improve quality of life. We would like to emphasize the importance of lifestyle changes, the management of major cardiovascular risk factors and the use of various prophylactic drug therapies in the prevention of cardiovascular diseases. Medical intervention strategies for high-risk patients include the use of acetilsalycilic acid, statin, beta-blocker, ACE-inhibitor and anticoagulant for the treatment of any disease where the use of such drugs has been supported by evidence. The specific preventive effect of a drug is considered to be verified if the drug significantly reduced the incidence of pirmary vascular outcomes, beyond its primary pharmacodynamic effect, or if it is likely to have such an effect according to adequately powered metaanalyses.]

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