Lege Artis Medicinae

[Clinical prognostic factor of breast cancer]

SVASTICS Egon1, RINGWALD Gábor2, SZÁMEL Irén2, TÓTH József3, BESZNYÁK István4

MAY 27, 1992

Lege Artis Medicinae - 1992;2(05)

[The authors are of the opinion that the investigation and determination of prognostic factors in breast cancer, like in any other malignant disease, are important. The data of their 744 breast cancer patients were studied by biostatistical methods. According to the results the state of nourishment, data of patient's reproductive life, number of abortions, cancer in the family and the localization of the tumor do not have any impact on survival. Concerning the age, the survival probability of post menopausal patients are better, while the premenopausal patients have the worst prognosis. The size of the tumor and especially the number of positive lymph nodes have the most significant influence on survival probability. The influence of estradiol receptor (ER) and progesteron receptor (PR) content of the primary tumor on survival was studied with respect to the other variables. The death rate decreases according to the increase of the receptor content, and the number of ER positive patients in the group with more than three positive lymph nodes is significantly lower. According to the results, the higher the ER content the less the number of local recurrences and metastases. ER positive patients are likely to have metastases in the bones. Most of the ER negative patients' metastases occurred already in the first three postoperative years. It is important to know the receptor content in order to determine the prognosis of the disease and establish adjuvant therapy and treatment in case of a later potential recurrence.]

AFFILIATIONS

  1. Budai MÁV Kórház Általános és Melkassebészeti Osztály
  2. Klinikai Kísérleti Laboratóriumi Osztály Országos Onkológiai Intézet, Budapest
  3. Humán és Kísérletes Patológiai Osztály Országos Onkológiai Intézet, Budapest
  4. Sebészeti Osztály Országos Onkológiai Intézet, Budapest

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