Lege Artis Medicinae

[Clinical implication of arterial stiffness in the elderly]

BENCZÚR Béla1

MARCH 31, 2022

Lege Artis Medicinae - 2022;32(03)

DOI: https://doi.org/10.33616/lam.32.008

Review

[Hypertension prevalence and cardiovascular risk gradually with age. However this aging process seems to take a more rapid course in some individuals, as reflected in the Early Vascular Aging (EVA) syndrome. Age and high blood pressure are the two main determinants of arterial stiffness which is the core of EVA: the impaired elasticity of the media layer of large elastic arteries (mainly the aorta), a process that can be measured by pulse wave velocity. In elderly hyperten­sives, large arteries stiffen and systolic and pulse pressures increase, due to wave reflections. Arterial stiffness has predictive value for future CV e.g. events, coronary artery dis­ease, stroke, and vascular dementia and even all-cause mortality. The concepts of EVA (Early Vascular Aging) and SUPERNOVA (Super­normal Vascular Aging, the opposite phenotype of EVA) help to understand why early target-organ damages develop in some individuals and why others remain much more “younger” than their chronologic age. New drugs are being developed to treat EVA when lifestyle intervention and conven­tional risk factor controlling drugs are not enough.]

AFFILIATIONS

  1. Tolna Megyei Balassa János Oktatókórház, I. Sz. Belgyógyászat (Kardiológia/Nephrológia)

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