Lege Artis Medicinae

[Clinical aspects of congenital thrombophilia]

DOMJÁN Gyula1, PÁL András2, PETŐ Iván3, SAS Géza4

MAY 29, 1991

Lege Artis Medicinae - 1991;1(09-10)

[In the recent decades the name ,,thrombophilia" has been accepted to denote the congenital, mostly inherited susceptibility to thromboses. The increased coagulability (hypercoagulation) is supposed to be the main cause of the evolution of congenital thrombophilia. Antithrombin III has an outstanding importance to neutralize the active factors developing in the course of the coagulative process, and heparin-cofactor 11 has become known recently. Protein C and protein S are also important regulators. The increased coagulability can be caused by congenital disturbances of the formation of fibrinogen and plasminogen and also by the decreased activity of the fibrinolytic system. Recently, we recognised several cases, where the cause of thrombophilia was simultaneous absence of two inhibitors of coagulation. We attach importance to those cases as well when the inherited defect of one inhibitor and a congenital metabolic disturbance occure together. The diagnosis of congenital thrombophilia needs a long series of laboratory tests. In the course of the treatment results can be expected from thrombolysis, probably from vascular surgical interventions and – in non recent cases – from anticoagulation. The substitution treatment is getting more important in these inhibitor deficiencies.]

AFFILIATIONS

  1. egyetemi adjunktus Orvostovábbképző Egyetem I. Belgyógyászati Klinika
  2. tanársegéd Orvostovábbképző Egyetem I. Belgyógyászati Klinika
  3. adjunktus Orvostovábbképző Egyetem I. Belgyógyászati Klinika
  4. egyetemi tanár Orvostovábbképző Egyetem I. Belgyógyászati Klinika

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