Lege Artis Medicinae

[Antianginal effects of verapamil]

KÉKES Ede1

JUNE 30, 1992

Lege Artis Medicinae - 1992;2(01 KLSZ)

[Verapamil is the prototype of the calcium antagonists. Administration of the drug produces a beneficial antianginal effect due to de creased preload and afterload through vasodilation without marked reflex tachycardia and also due to a special influence on myocardium (negative inotropy and positive lusitropy) in all forms of ischaemic heart disease. Verapamil is also a strong coronary dilator drug. Verapamil was given in doses of 240–360 mg daily. The investigators concluded that exercise tolerance increased and the number of anginal attacks and nitroglycerin (sublingual) consumption decreased. The rate-pressure product is reduced on verapamil. Its cardio protective effect on myocardial structure is still an object of discussion.]

AFFILIATIONS

  1. Orvostovábbképző Egyetem II. Belgyógyászati Klinika Budapest

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