LAM KID

[Determining sclerostin level in healthy men]

MOLNÁR Zsuzsanna1, WAMWAKI John1, PETHŐ Zsófia2, KALINA Edit1, FÖLDESI Róza1, BALOGH Ádám3, ANTAL-SZALMÁS Péter1, BHATTOA Harjit Pál1

MAY 30, 2014

LAM KID - 2014;4(02)

[The aim of this study is to evaluate the relationship of serum sclerostin levels with age, cystatin C, bone mineral density (BMD) and biochemical markers of bone turnover in healthy Hungarian men over 50 years of age. We determined serum levels of sclerostin and examined its relationship with age, cystatin C, osteocalcin, C-terminal telopeptides of type-I collagen, procollagen type 1 amino-terminal propeptide, 25- hydroxyvitamin D, parathyroid hormone, and L1-L4 (LS) and femur neck (FN) BMD data available from 194 randomly selected ambulatory men belonging to the HunMen cohort. In the study population as a whole (n=194; age (median, range): 59 (51-81) years), statistically significant correlation was found between sclerostin and age (r=0.211; p=0.003), cystatin C (r=0.246; p=0.001), FN-BMD (r=0.147; p=0.041) and LS BMD (r=0.169; p=0.019). Compared with middle-aged men (age: ≤ 59 years, n=98), elderly men (age > 59 years, n=96) had significantly higher serum sclerostin levels (67.8±15.9 pmol/l vs. 63.5±14; p=0.047). Among men with normal (T score >-1,0) FN-BMD, the elderly had significantly higher serum sclerostin levels as compared with the middle-aged (70.4±17 pmol/l vs. 63.9±11.5 pmol/l; p=0.019). Furthermore, among the elderly men cystatin C was the only significant predictor of serum sclerostin levels (standardized regression coefficient (béta) = 0,487; p<0,001). Our results show that in the studied healthy elderly cohort sclerostin levels significantly increase with age, along with the deterioration of kidney function as determined by plasma cystatin C levels. ]

AFFILIATIONS

  1. Debreceni Egyetem, Orvos- és Egészségügyi Központ, Laboratóriumi Medicina Intézet
  2. Debreceni Egyetem, Orvos- és Egészségügyi Központ, Reumatológiai Tanszék
  3. Regionális Osteoporosis Centrum, Szülészeti és Nôgyógyászati Klinika

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