Journal of Nursing Theory and Practice

[Research for Nurses 3. part: Analysis in Brief]

TAKÁCS Péter, PAPP Katalin, RADÓ Sándorné

DECEMBER 31, 2013

Journal of Nursing Theory and Practice - 2013;26(06)

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Journal of Nursing Theory and Practice

[Christmas Greetings]

Journal of Nursing Theory and Practice

[The health care changes affected the everyday lives of nurses ]

NÉMETH Anikó, BETLEHEM József, LAMPEK Kinga

[Aims of the study: To examine the changes inpatient care nurses had to undergo following the reorganization of health care system during the last few years. Sample and methods: This was a cross-sectional study conducted in six teaching hospitals of Hungary involving nurses who worked full-time in inpatient care applying self-developed questionnaires between October and December 2010. Results: Nurses had to face many negative events and the feeling of uncertainty during the reorganization, which also affected the self evaluation of their health status. The fear of relocation, reduced salary or losing the job and the worsened psychic status and bad workplace communication are significant. The six-question uncertainty scale can be divided into a promotional and an environmental subscale. Responders expect significant support from their employers, mainly financially. Conclusions: The reorganization of the health care system caused uncertainty by the nurses. ]

Journal of Nursing Theory and Practice

[Hungary is the cradle of Occupational Health Nursing Education ]

HIRDI Henriett Éva

[Aim of the study: To research the origin and story of the Occupational Health Nursing in Hungary, to present the development of the factory nurse institutions which fell into oblivion by this time. Sample and Method: Collect and work up literature sources and legislation systematically issued between 1840 and 1950. Examine extant correspondence and reports of factories, enterprises and finishing-schools functioned before the socialization. The examined issues were the followings: aspects of the selection of those who fill factory nurse scope of activities, their qualification, role and esteem. Results: It was found that factory nurses were not selected out of working women. The first factory nurse course started in 1933 in Budapest. During ten years 150 students fulfilled the two-years full-time course based on the secondary education. Participants of the course had to suit strict admission requirements. Students of the course learnt about health, social, legal and cultural knowledge from noted professionals at that time. Factory nurses performed their activities basically at two locales: inside and outside of the factory. Qualified factory nurses were hold in great honour socially, even their rights were protected by collective agreement. Conclusions: Occupational Health Nurse Education has a 80-years-old history in Hungary, that throw new light upon theories until now about origin of Occupational Health Nursing. ]

Journal of Nursing Theory and Practice

[Childhood obesity]

KORMOS-TASI Judit, SZABÓ László, GÁCSI Erika

[The obesity is a worldwide problem in all agegroup. In 1998 the WHO gives forth that the obesity is an illness. In Hungary the frequency of obesity today is 7 % at the age of 17. The childhood obesity is a main risk of morbidity in the adulthood. There atre two parts of the prevention: sports and excersises and healthy nutrition. In the health prevention we have to take aim at these two methods, so this is the right way to the successfull results. ]

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Electrophysiological investigation for autonomic dysfunction in patients with myasthenia gravis: A prospective study

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Myasthenia gravis (MG) is an autoimmune disorder of neuromuscular transmission. Autonomic dysfunction is not a commonly known association with MG. We conducted this study to evaluate autonomic functions in MG & subgroups and to investigate the effects of acetylcholinesterase inhibitors. This study comprised 30 autoimmune MG patients and 30 healthy volunteers. Autonomic tests including sympathetic skin response (SSR) and R-R interval variation analysis (RRIV) was carried out. The tests were performed two times for patients who were under acetylcholinesterase inhibitors during the current assessment. The RRIV rise during hyperventilation was better (p=0.006) and Valsalva ratio (p=0.039) was lower in control group. The SSR amplitudes were lower thereafter drug intake (p=0.030). As much as time went by after drug administration prolonged SSR latencies were obtained (p=0.043).Valsalva ratio was lower in the AchR antibody negative group (p=0.033). The findings showed that both ocular/generalized MG patients have a subclinical parasympathetic abnormality prominent in the AchR antibody negative group and pyridostigmine has a peripheral sympathetic cholinergic noncumulative effect.

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Sandhoff disease is a rare type of hereditary (autosomal recessive) GM2-gangliosidosis, which is caused by mutation of the HEXB gene. Disruption of the β subunit of the hexosaminidase (Hex) enzyme affects the function of both the Hex-A and Hex-B isoforms. The severity and the age of onset of the disease (infantile or classic; juvenile; adult) depends on the residual activity of the enzyme. The late-onset form is characterized by diverse symptomatology, comprising motor neuron disease, ataxia, tremor, dystonia, psychiatric symptoms and neuropathy. A 36-year-old female patient has been presenting progressive, symmetrical lower limb weakness for 9 years. Detailed neurological examination revealed mild symmetrical weakness in the hip flexors without the involvement of other muscle groups. The patellar reflex was decreased on both sides. Laboratory tests showed no relevant alteration and routine electroencephalography and brain MRI were normal. Nerve conduction studies and electromyography revealed alterations corresponding to sensory neuropathy. Muscle biopsy demonstrated signs of mild neurogenic lesion. Her younger brother (32-year-old) was observed with similar symptoms. Detailed genetic study detected a known pathogenic missense mutation and a 15,088 base pair long known pathogenic deletion in the HEXB gene (NM_000521.4:c.1417G>A; NM_000521:c.-376-5836_669+1473del; double heterozygous state). Segregation analysis and hexosaminidase enzyme assay of the family further confirmed the diagnosis of late-onset Sandhoff disease. The purpose of this case report is to draw attention to the significance of late-onset Sandhoff disease amongst disorders presenting with proximal predominant symmetric lower limb muscle weakness in adulthood.