Hypertension and nephrology

[Too early publication? (priority of the Hungarian authors was saved by a South- American radiologist)]

RADÓ János

MAY 20, 2012

Hypertension and nephrology - 2012;16(02)

[It is supposed that the invention of diuretic (furosemide) renography was a premature discovery. This is suggested by the fact that it was rediscovered by more than one people. Author supported this contention by a statistical analysis of „citation intervals” performed on the basis of Garfield’s suggestions. The length of the time from the description of the procedure to the appearance of citations („citation interval”) proved to be an average of 21.3±9.6 (SD) years, significantly longer than in the case of the author’s five important other recognitions combined, where the average citation interval was 8.7±7.4 (SD) years (p<0.01). Camargo a South-American radiologist who first confirmed the original study, was later just in time the editor of a North American journal to save the priority of the original inventor Hungarian authors. In medical science the investigators take the risks in the interest of the patients including „publishing too early”.]

COMMENTS

0 comments

Further articles in this publication

Hypertension and nephrology

[The 20th Jubilee Congress of the Hungarian Society of Hypertension]

Hypertension and nephrology

[May patients with chronic kidney disease do sports?]

APOR Péter, RÁDI Attila, BABAI László

[Physical activity and sports in healthy people do not result in renal impairment. In end-stage renal disease - together with dialysis - moderate physical activity supports the maintenance of the controlled status. In chronic kidney disease moderate exercise improves filtration, the lipid profile, diminishes proteinuria and oxidative damage, maintains the muscular performance and metabolically active muscle mass. Metabolism of diabetics are significantly improved with exercise, it provides renal protection. Excess consumption of proteins, non-steroidal antiinflammatory drugs or creatine can be a problem in competitive sports. The high muscle mass implies higher creatinine level.]

Hypertension and nephrology

[Róbert Langer (Editor): History of the Baross Street Surgery Clinic]

ALFÖLDY Ferenc

Hypertension and nephrology

[Gender differencies in coronary reactivity in angiotensin II hypertension rat model]

MÁTRAI Máté, NÁDASY György L, HETHÉSSY Judit, SZEKERES Mária, Monos Emil, SZÉKÁCS Béla, VÁRBÍRÓ Szabolcs

[It is known that hypertension shows several gender specific elements both in pathogenesis and in therapy. Understanding this phenomenon may bring us closer to individualized therapy. That was the reason why we examined process of hypertensive adaptation on the level of small intramural coronary arteries. 10-10 male and female Sprague-Dawley rats were used in this study. Animals received osmotic pumps in anaesthesia, which emitted 100 ng/bwkg/min angiotensin II acetate for four weeks. After four weeks treatment, animals were sacrified and heart weights were measured. We isolated intramural, small branches of the left anterior descendant coronary artery, placed them into vessel chamber and tested biomechanical properties and pharmacological reactivity. Heart weight and wall thickness were higher in females comparing to males. However, basal vascular tone and thromboxane-mediated vasoconstriction were elevated in males. Bradykinin relaxation was bigger in females. In female animals inward eutrophic remodeling was found, while in males increased wall stress and elastic moduli dominated the adaptation process. In conclusion, initial steps of angiotensin II mediated hypertension induced markedly gender dependent alterations.]

Hypertension and nephrology

[Position Paper Concerning the Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers (Inhibition of the Renin-Angiotensin System) in Chronic Renal Disease]

MÁTYUS János, KISS István

All articles in the issue

Related contents

Hypertension and nephrology

[Attracted by science III. - My scientific life product of 55 years: what have I achieved?]

dr. RADÓ János

[Author analyses the scientific results of his own clinical research work by evaluating his product in a „traditional way”, and only after then supplemented by scientometric data (citedness). From the 148 articles which has been published in foreign language (mostly in English) in abroad, 10 was grouped into the category of “new procedure/ recognition”, 40 into “original data/significant new statement”, and 98 into “new observation (statement) in a detailed question”. He has found close correlation between the values of the publications grouped by the traditional evaluation and the corresponding numbers of citations. Author discusses in the light of his own data the evaluating role of citedness with the hope to help by this motivated young scholars to plan their own future.]

Hypertension and nephrology

[My teacher, Pál Gömöri (1905-1973)]

RADÓ János

[Great Hungarian physicians have contributed a lot to the development of international medical science. Pál Gömöri was one of them. It is impossible to list the versatility of his scientific interests, but one of his ambitions was the introduction of the investigational methods of renal nuclear medicine to Hungary. The author’s feeling is that his own activity in renal nuclear medicine concerning “diuretic renography” was inspired partly by the information which was learned from Gömöri. The scientific results produced by Gömöri will be preserved in the libraries and on the internet. The spirit of his medical teaching, however, must be passed over by his students and followers, to provide his remembrance to fade as late as possible ]

Hypertension and nephrology

[Combination of diuretics in resistant hypertension]

RADÓ János

[Resistant hypertension developed in a 60-year-old male patient with chronic renal insufficiency due to untreated high blood pressure for decades despite of the coadministration of furosemide, β-blocker, calcium channel blocker, angiotensin converting enzyme inhibitor and angiotensin receptor blocker. Breakthrough could be achieved by the combination of a tiazide compound and a loop diuretic (furosemide). It seemed to be worthwile publishing the case because the tiazide drug could be successfully administered below 30 ml/min GFR, where it is generally thought to be ineffective, and because both elements of the combination was given in very low doses relative to the kidney disease. The literature of the most important combinations of the tiazide preparations and the loop diuretics are reviewed and some historical aspects are given as well.]