Hypertension and nephrology

[Role of IL-10 family of cytokines in kidney fibrosis]

PAP Domonkos1, VERES-SZÉKELY Apor2, SZEBENI Beáta1, SZIKSZ Erna1, KISS József Zoltán1, TAKÁCS István Márton2, REUSZ György2, SZABÓ J. Attila1,2, VANNAY Ádám1,2

SEPTEMBER 10, 2019

Hypertension and nephrology - 2019;23(04)

DOI: https://doi.org/10.33668/hn.23.018

[Chronic renal failure is a major health problem, affecting 8 to 16% of the population. Regardless of the etiology the common hallmark of chronic renal failure is inflammation, leading to the activation of renal myofibroblasts. Chronic activation of myofibroblasts lead to abnormal accumulation of extracellular matrix, disruption of the architecture of the kidney and finally to reduced renal function. Although our knowledge is rapidly expanding about the pathomechanism of chronic renal failure, we still have no drug to treat or hinder the progression of the disease. In our present review article, we summarize the role of the cytokines of the IL-10 family in renal scarring.]

AFFILIATIONS

  1. MTA-SE Gyermekgyógyászati és Nefrológiai Kutatócsoport, Budapest
  2. Semmelweis Egyetem, I. Sz. Gyermekgyógyászati Klinika, Budapest

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