Hypertension and nephrology

[Hypertension and Covid-19 – Part I. Significance of age, underlying diseases, and ACEI/ARB therapy in hypertension and co-morbidities during SARS-Cov2 infection]

KÉKES Ede1, SZÉKÁCS Béla2, NAGY Judit3, KOVÁCS Tibor3

JUNE 24, 2020

Hypertension and nephrology - 2020;24(3)

DOI: https://doi.org/10.33668/hn.24.011

[The appearance of the Covid-19 epidemic in different continents shows specific clinical features. Confirmed infected patients are detectable from approximately 30 years, with a maximum between 40 and 70 years of age. At the same time, however, a significant proportion of those who die from the infection come from patients over 65 years. The prevalence and mortality rates of the hypertensive population show a very similar formation. Based on the data collected, it is not surprising that hypertension as the underlying disease in the Covid- 19 epidemic is the first in all analysis. A more precise analysis clarified that it is not hypertension per se, but co-morbidities and complications of hypertension that play a primary role behind large-scale mortality in old age, such as diabetes, coronary heart disease, stroke, heart failure, and chronic kidney disease. Data from China, North America, and Italy suggest that hypertension and diabetes – and in North America, pathological obesity – in infected patients actually only reflect the prevalence of these diseases in a given population. The presence of comorbidities (coronary artery disease, stroke, heart failure, arrhythmia, chronic kidney disease) – based on multivariate logistic regression analysis – presents a more risk for severe clinical course and mortality. Some recent analyses have provided strong evidence that ACEI/ARB treatment does not pose a higher risk for the course or outcome of infection. Their administration is constantly needed in hypertension and comorbidities due to their organ protective and slowing the progression of diseases.]

AFFILIATIONS

  1. Pécsi Tudományegyetem, Orvostudományi Kar, Klinikai Központ, Kardiológiai Tanszék, Pécs
  2. Szent Imre Egyetemi Oktatókórház, Geriátriai és Gerontopszichiátriai Rehabilitációs Osztály; Semmelweis Egyetem, II. Belgyógyászati Klinika, Geriátriai Tanszéki Csoport, Budapest
  3. Pécsi Tudományegyetem, Orvostudományi Kar, Klinikai Központ, II. Sz. Belgyógyászat Klinika és Nefrológiai, Diabetológiai Centrum, Pécs

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