Clinical Oncology

[Geriatric oncology]


MAY 10, 2017

Clinical Oncology - 2017;4(02)

[Geriatric oncology has an increasing role since in several types of cancer the median age at diagnosis is above 60 years of age. The treatment of elderly patients are frequently set back by prejudice, stereotypes and lack of information. All these lead to the fact that even in well-developed countries elderly cancer patients often do not receive the necessary treatments. This is even more true in poor-countries, where the fi nancial defi cit accumulated in health care is often attempted to be reduced by the treatment of elderly. If a paediatric oncology patient does not get suffi cient cancer treatment there is a fi erce protest, but everybody is silent if this occurs in the case of an 80 years old patient. For this unacceptable situation both authorities (fi nancing) and professional bodies (treatment, education) are responsible. Clinical data show that elderly cancer patients get the same benefi t of active oncology treatment, as younger ones. Age on its own does not contraindicate any cancer treatment. The aim of this review is to prove by data, that elderly cancer patients should also get active oncology treatment. The questions of assessment include frailty, the relationship of cancer development and ageing, and other problems related to the oncology treatment of elderly patients are also discussed.]



Further articles in this publication

Clinical Oncology


A szerkesztők

Clinical Oncology

[News from the World]

Clinical Oncology

[Adjuvant treatment of breast cancer]


[Choice of optimal adjuvant treatment has been based on present debates, doubts and commit offence against processing or existing evidences. Clinical research has been resulted changes and renewal of practice decisions continuously. 3rd Breast Cancer Consensus Conference held on Kecskemét last year corresponded by Hungarian experts of the fi eld has given up to date and well-defi ned guideline. Present paper try to give a summary of adjuvant treatment courses for early breast cancer in consideration of last results of research since then.]

Clinical Oncology

[Combination of radiotherapy and immunotherapy]

HIDEGHÉTY Katalin, BRUNNER Szilvia, SZABÓ Zoltán Imre, SZABÓ Emília Rita, POLANEK Róbert, TŐKÉS Tünde

[Increasing experimental and clinical evidences demonstrated the synergic effect between the rapidly implemented immunotherapy and advanced forms of focal radiotherapy, not only on the elimination of the irradiated lesion, but also on the enhancement the immune-mediated systemic anti-tumoral activity. It is essential for gaining the most benefi t from the combination of the two modalities to select the appropriate patients, to defi ne the irradiation parameters, such as radiation quality (ie. particle) dosage, (total dose, fraction number) size of the target volume, the use of other supportive and anti-tumor drugs. In this review, we provide an update for the daily oncological practice on the data accumulated up to now on the molecular basis and patomechanism of enhancing radio-immune effect and clinical results, and highlight the most important parameters, which may increase the abscopal effect of ionizing radiation, thereby increasing the effectiveness of immunotherapy. However, development of clinical guidelines for benefi cial integration of immunotherapy and radiotherapy could be expected after evaluation the result of currently ongoing numerous (> 100) clinical trials. If the preclinical results will be confi rmed clinically, it could lead to paradigm shift in the use of ionizing radiation.]

Clinical Oncology

[Why don’t immune checkpoint inhibitors work in colorectal cancer?]

SHI Yuequan, ZOU Zifang, KERR David

[In recent years, immune checkpoint inhibitors have been shown to be effective in treating manifold types of cancer but less robust in colorectal cancer (CRC). While, the subgroup of CRC with microsatellite instability (MSI; also termed as mismatch repair defi cient) showed a moderate response to Pembrolizumab in a single arm phase II clinical trial, microsatellite stable (MSS) cancers were unresponsive. Possible mechanisms that affect immune response in colorectal cancer will be reviewed in this article. We will also propose that histone deacetylase (HDAC) inhibition may reverse the immune editing commonly seen in advanced CRC and render them sensitive to immune checkpoint blockade.]

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[What is the doctor like, if female? - Female doctors’ ideal image based on empirical studies]

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[The aim of our study was to examine thestereotypes about female doctors and howdo the female medical students perceivethe working female doctors whom are theirrole models. In the first study (247 from theAlbert Szent-Györgyi Medical and Pharma-ceutical Centre at the University of Szegedand 256 from the Medical and HealthScience Centre of the University ofDebrecen) the female medical students’professional socialization was compared tothe male counterparts’. In the second study(from University of Szeged, 214 femalemedical students, 132 female jurist stu-dents) female medical and jurist students'professional socialization was comparedincluding the comparison of stereotypes inconnection with working female doctorsand jurists. Female medical students’ professionalsocialization is different that of male coun-terparts in several aspects: being morealtruistic, more family centered, gettingcommited to the profession earlier, havingmore ambiguous carrier planes, and asmaller percentage of their parents’ has adegree or is a medical doctor, then for malemedical students. The female medical doc-tor has positive, idealistic, altruistic charac-ters according to both female studentgroups’ opinions. The female doctor’simage is more often associated with char-actersitics implying problems by femalemedical students then jurists. The unfold-ing image of these stereotypes is a femaledoctor who is willing to help, however,faceing lots of hardnesses during work.If the female medical students’ image of theproblematic life of these idealistic femaledoctors’ is known, it provides an opportu-nity to prepare them for the hardnessesthey’ll face avoiding role conflicts andhealth problems in the future.]

Clinical Neuroscience


POZSEGOVITS Krisztián, KAZUO Suzuki, NAGY Zoltán

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