Clinical Neuroscience

Über einige neurophysiologischen Aspekte der Schizophrenie


JUNE 01, 1985

Clinical Neuroscience - 1985;38(06)

Die bioelektrische Aktivität des Gehirns (BEA) unserer Definition nach wenn sie auch ein „Paraphenomen" der höheren Nerventätigkeit darstellt und das nicht ihren Inhalt in sich kodieren kann, steht jedoch in bestimmten Korrelationen mit ihr. Im allgemeinen kann sie als Indikator des funktionellen Zustandes des Gehirns und seiner Reaktivität dienen.



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Clinical Neuroscience

[The value of the carotid compression test for cerebral circulatory disorders ]


[The authors report the results of carotid tests performed in 233 patients with carotid territory and 94 patients with vertebro-basilar circulation disorders, as well as in 1940 outpatients, along with clinical data and neurological status. On the basis of these data, it is considered that carotid tests are a useful tool for the selection of a patient population requiring detailed clinical screening and for the assessment of the functional value of the current carotid circulatory capacity. ]

Clinical Neuroscience

[Centronuclear myopathy ]

GÁTI István, CZOPF József, TROMBITÁS Károly

[The authors describe the medical history of a mother and daughter with centronuclear myopathy. The mother's disease began with clinical signs of neural isomatrophy, and later clinical, electrophysiological, and histological examinations confirmed myopathy. In her daughter, histopathological examination demonstrated centronuclear myopathy with type I muscle fibre hypotrophy. Sural biopsy showed severe degeneration of the peripheral nerve. Clinical, electrophysiological and histological data of both patients documented peripheral nerve damage in centronuclear myopathy. ]

Clinical Neuroscience

[Our behavioural therapy experience with aggressive pediatric patients ]


[In the first part of the publication the authors deal with the theoretical foundations of the behavioral therapy of aggressiveness. It is emphasized that the goal of treatment is not the suppression of aggressiveness, but its socialized expression or transformation into creativity. The second part reports on the experience gained in the treatment of 14 patients in childhood. By means of a detailed case description, the implementation of the principles described at the beginning is shown in practice and the personnel and equipment conditions for successful therapy are discussed. ]

Clinical Neuroscience

[Physical pre-development silvering process for the indication of axial threads on frozen and paraffin sections ]


[ Using sodium dodecyl sulfate pretreatment and silicotungstic acid physical developer, the author has developed a simple and reliable method for the deposition of axial yarns on frozen or paraffin-embedded materials.]

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[Effective therapy in highly active pediatric multiple sclerosis ]

MERÔ Gabriella, MÓSER Judit, LIPTAI Zoltán, DIÓSZEGHY Péter, BESSENYEI Mónika, CSÉPÁNY Tünde

[Multiple sclerosis (MS) is typically a disease of young adults. Childhood MS can be defined in patients under 18 years of age, although some authors set the limit un­der the age of 16 formerly known as “early-onset multiple sclerosis” or “juvenile multiple sclerosis”, seen in 3-5% of all MS patients. Nowadays, owing to ever-evolving, better diagnostic tools and well-traced, strictly defined diagnostic criteria, childhood MS is showing an increasing incidence worldwide (0.05-2.85/100 000). MS is characterized by recurrent episodes of the central nervous system with demyelination separated in space and time. In childhood almost exclusively the relapsing-remitting (RR) type of MS occurs. Based on experience in adults, the goal in the pediatric population is also the early diagnosis, to initiate adequate DMT as soon as possible and to achieve symptom relief and good quality of life. Based on efficacy and safety studies in the adult population, inter­feron β-1a and glatiramer acetate were first approved by the FDA and EMA for the treatment of childhood MS also. The increased relapse rate and rapid progression of childhood MS and unfavorable therapeutic response to nearly 45% of the first DMT necessitated the testing of more effective and second-line drugs in the population under 18 years of age (PARADIGMS, CONNECT). Although natalizumab was reported to be effective and well-tolerated in highly active RRMS in childhood, evidence based studies were not yet available when our patients’ treatment started. In this article, we report on the successful treatment of three active RRMS patients with individually authorized off-label use of natalizumab.]

Lege Artis Medicinae

[Mephistopheles of the human faced psychiatry. Klára Muhi – András Dér: The crazy circles of freedom]

BENKE Attila

Clinical Neuroscience

Die medizinische Psychologie als Theoretische Grundlage der allgemeinen Medizin

W. Iwanow

Die medizinische Psychologie ist gerade das Fach, das diese wesentliche Schwäche der heutigen Medizin überwindet und einen vollständigen Zugang zum Kranken zu schaffen (oder dazu beizutragen) pflegt. Hier geht es nicht nur um eine ,,mechanische Vereinigung" des Somas und der Psyche, sondern um ein tiefstes und vollständigstes Verstehen des psycho-physiologischen Wesens des Menschen.

Lege Artis Medicinae

[Primary care strategy of antihypertensive treatment of very elderly and frail patients]

TORZSA Péter, KALABAY László, CSATLÓS Dalma, HARGITTAY Csenge, MÁRKUS Bernadett, MOHOS András, SZIGETI Mátyás, FERENCI Tamás, MARJOLEIN Verschoor, ROZSNYAI Zsofia, JACOBIJN Gussekloo, ROSALINDE K. E. Poortvliet, SVEN Streit

[BACKGROUND - When treating very el­der­ly and frail hypertensive patients, there have to be taken in account the general health condition and frailty of patients, the present cardiovascular diseases (CVD) and values of the systolic blood pressure (SBP). Goals - In a clinical study performed in 29 countries, we aimed to analyse differences in practical antihypertensive therapy of family doctors among patients older than 80 years; further we sought to answer how much was influenced their therapeutic choice by frailty of the old age. The other goal of our study was to compare Hungarian versus international outcomes. Methodology - As part of an online survey, family practitioners had to decide about necessity of starting antihypertensive treatment among very elderly patients according to different patterns of frailty, SBP and CVD. The ratio of specific cases with positive treatment decision of family practitioners was compared in all 29 countries. We used a logistic mixed model analysis to multivariately model the role of frailty. Results - 2543 family practitioners participated in the cross-national study; 52% were female; 51% practised in urban environment. In 61% of practices, there was the ratio higher than 10% of very elderly patients. Hungary participated with 247 family practitioners in the study; 52.3% were female; 63.1% practised in urban environment. In 48.8% of practices the ratio of very elderly patients was higher than 10%. In 24 out of the 29 countries (83%), frailty was associated with GPs’ negative decision about starting treatment even after adjustment for SBP, CVD, and GP characteristics (odds ratio [OR 0.53]), 95% CI: 0.48-0.59; ORs per country 0.11-1.78). The lowest treatment ratio was in the Netherlands (34.2%; 95% CI: 32.0-36.5%) and the highest one in Ukraine (88.3%; 95% CI: 85.3-90.9%). In Hungary’s treatment ratio ranged 50-59%. This country ranked on the 27th place since Hungarian family practitioners chose rather to start antihypertensive treatment despite the frailty of the patient (OR=1.16; 95% CI: 0.85-1.59). Hungarian family practitioners started pharmacotherapy of elderly patients more frequently if they were males (OR= 1.45; 95% CI: 0.81-2.61), were working in their practice for less than 5 years (OR=2.41; 94% CI: 0.51-11.38), and if they had many patients aged over 80 years in their practice (OR=2.18; 95% CI: 0.70-6.80), however these differences were sta­­tistically not significant. Among Hun­ga­rian family practitioners starting therapy was significantly influen­ced by cardiovascular disease (OR=3.71; 95% CI: 2.64-5.23) and a SBP over 160 mmHg (OR=190.39; 95% CI: 106.83-339.28). Conclusions - In our study, there was significant difference between countries in starting antihypertensive treatment for very elderly patients. However, Hungary was among the countries where family practitioners preferred to treat their frail patients. The patients’ frailty did not have any impact on starting the therapy; rather cardiovascular disease and a SBP over 160 mmHg decided. It is an important message of the study that there is continuous need to educate family practitioners and trainees about the treatment of frail, elderly hypertensive patients.]

Clinical Neuroscience

Die Bedeutung der Kinderneuropsychiatrie für die Kindererziehung

GERHARD Göllnitz

Nach einem Überblick über die neuropsychiatrischen Probleme von Kindern mit verschiedenen genetischen Ursprüngen und Bildungsdefiziten hebt der Autor die besondere Bedeutung der Früherkennung hervor. Neben der Prophylaxe sind die frühzeitige Erkennung von Entwicklungsstörungen und eine frühzeitige Therapie die einzige Möglichkeit, eine wirksame medizinische Intervention zu gewährleisten. Der Autor stellt ein in Rostock entwickeltes Verfahren zur Früherkennung vor. Diese Regelung sollte auf Kinder im Alter von 6, 15 Monaten und 3 Jahren angewendet werden.