Clinical Neuroscience

[Thrombolysis in the treatment of acute ischemic stroke]

NAGY Zoltán1, SKOPÁL Judit2

MARCH 20, 1994

Clinical Neuroscience - 1994;47(03-04)

[Stroke is the third common cause of death and the main cause of disability in Hungary. Despite of the intensive preclinical and clinical research on the pathophysiology and therapy of ischemic stroke, there is no treatment to improve the prognosis of brain infarct. Thrombolysis could be hypothetically a causative intervention, what makes the vascular bed patent again (recanalisation hypothesis). The different thrombolysis trials, meta-analysis, and case reports indicated, that the early hospitalisation, well planed diagnostic algorithm including CT and analysis of hemostasis factors are important. The high risk complications like haemorrhagic transformation of the infarct or edema are not dose related. Timing of the lysis therapy is fundamental, therefore the well organised stroke management in our country seems to be a basic factor in the acute treatment of stroke patients.]

AFFILIATIONS

  1. Semmelweis Orvostudományi Egyetem, Pszichiatriai és Pszichoterápiás Klinika Cerebrovascularis Osztály, Budapest
  2. Sanofi-Chinoin Haemostasis Laboratórium, Budapest

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