Clinical Neuroscience

[Seduxen treatment in certain neurological diseases (neurosis, pain, muscle spasm)]


DECEMBER 01, 1968

Clinical Neuroscience - 1968;21(12)

[Seduxen 5 mg tabl., produced by Kőbánya Pharmaceuticals, has been used in clinical therapeutic trials. Out of 100 patients in the ward, 77 were in different groups of neurasthenia, - neurosis, 7 patients were treated for pain caused by organic disease, 16 for muscle spasm and contracture. He discusses the 8 groups of neurasthenia-neurosis listed and finds that the highest improvement rates were in the reactiv and vasovegetative groups, 82.7% in the former and 83.3% in the latter. The overall improvement rate for all groups was 77.8%. The 75% improvement in neurasthenia anxiosa is highlighted, following the anxiolytic effect of diazepam highlighted by both foreign and national researchers. These results suggest that Seduxen is a very good tranquillant drug, which, at the right dose (3 X 14, 3 X 12, 3 X 1 tablets daily), has a sedative effect without side effects. Seduxen also has a direct analgesic and analgesic effect, not only in arthritis and arthrosis of various types, but also in polyneuritis, neuritis and neuralgia. Seduxen is an excellent muscle relaxant, which has been observed in 13 of its 16 organic patients to a marked degree and in three to a moderate degree; by reducing the dose sufficiently, a detrimental degree of muscle weakness can be avoided. Dose: 3x1/2 tablets daily is recommended as the initial dose, but in the vast majority of patients 3x1 tablets daily was adequate; in some cases 3x 14 tablets daily proved beneficial. Experience has shown that the side effects of Seduxen are mild, exceeding those of known tranquillant drugs only in cases of overdose or individual hypersensitivity. A certain degree of drowsiness is relatively common, but this, like muscle hypotension in paretic patients, can be avoided by reducing the dose appropriately. ]


  1. Fővárosi István Kórház Idegosztály



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[Book review]


[The author presents Bechtereva, N. P., Bondarchuk, A. N., Smirnov, B. M. and Trohachev, A. 1.: Physiology and pathophysiology of deep structures of the human brain.]

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